Findings

What do systematic reviews say?

996 questions · 1,049 findings · 79 reviews · Dementia and Cognitive Improvement

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No studies found 240 · 22.9%GRADE not reported 31 · 3%Very low 216 · 20.6%Low 253 · 24.1%Moderate 238 · 22.7%High 71 · 6.8%

Pharmacological agents vs placebo

Cognitive performance on psychometric tests · Participants with chronic cognitive impairment in traumatic brain injury

1 finding from 1 review

Pharmacotherapy for chronic cognitive impairment in traumatic brain injury 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 274 participants
Very low

Pharmacological agents vs placebo

Clinical global improvement · Participants with chronic cognitive impairment in traumatic brain injury

1 finding from 1 review

Pharmacotherapy for chronic cognitive impairment in traumatic brain injury 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 51 participants
Low

Pharmacological agents vs placebo

Acceptability · Participants with chronic cognitive impairment in traumatic brain injury

1 finding from 1 review

Pharmacotherapy for chronic cognitive impairment in traumatic brain injury 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 274 participants
Very low

Pharmacological agents vs placebo

Safety · Participants with chronic cognitive impairment in traumatic brain injury

1 finding from 1 review

Pharmacotherapy for chronic cognitive impairment in traumatic brain injury 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 274 participants
Very low

Pharmacological agents vs placebo

All‐cause mortality · Participants with chronic cognitive impairment in traumatic brain injury

1 finding from 1 review

Pharmacotherapy for chronic cognitive impairment in traumatic brain injury 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 274 participants
GRADE not reported

Intervention not reported

Cognitive function ‐ the Cognitive portion of the Alzheimer Disease Assessment Scale ADAS‐Cog1 · Huntington's disease

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Intervention not reported

Cognitive function ‐ Wechsler Memory Scales WMS‐general memory score1 · Multiple sclerosis

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Intervention not reported

Cognitive function ‐ Selective Reminding Test total SRT1 · Multiple sclerosis

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 270 participants
High

Intervention not reported

Clinical global impression of change ‐ patient's self‐reported impression of memory change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ patient's self‐reported… (high certainty).

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
OR 1.67 [0.93, 3]
2 studies · 189 participants
High

Intervention not reported

Clinical global impression of change ‐ patient's self‐reported impression of cognitive change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ patient's self‐reported… (high certainty).

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
OR 0.95 [0.45, 1.98]
1 study · 120 participants
High

Intervention not reported

Clinical global impression of change ‐ clinician's impression of memory change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ clinician's impression of… (moderate certainty).

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
OR 1.95 [0.88, 4.3]
1 study · 120 participants
Moderate

Intervention not reported

Clinical global impression of change ‐ clinician's impression of cognitive change · Multiple sclerosis

The intervention leads to higher clinical global impression of change ‐ clinician's impression of… (high certainty).

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
OR 1.96 [1.06, 3.62]
2 studies · 189 participants
High

Intervention not reported

Activities of daily living ‐ Patient reported impact of multiple sclerosis activities Patient reported impact of multiple sclerosis activities1 · Multiple sclerosis

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
Low

Intervention not reported

Cognitive function ‐ the Cognitive portion of the Vascular Alzheimer Disease Assessment Scale change V‐ADAS‐Cog1 · CADASIL

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 161 participants
High

Intervention not reported

Clinical global impression of change ‐ the Sum of Boxes of the Clinical Dementia Rating Scale CDR‐SB1 · CADASIL

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 161 participants
High

Intervention not reported

Activities of daily living ‐ Disability Assessment for Dementia scale DAD1 · CADASIL

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 161 participants
Moderate

Intervention not reported

Cognitive function ‐ the Unified Huntington's Disease Rating Scale‐Symbol Digit Modalities Test change UHDRS‐SDMT1 · Huntington's disease

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Intervention not reported

Nausea · Patients with neurological conditions associated with rarer dementias

The intervention leads to higher nausea (high certainty).

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
OR 2.1 [1.22, 3.62]
6 studies · 503 participants
High

Intervention not reported

Diarrhea · Patients with neurological conditions associated with rarer dementias

The intervention probably leads to higher diarrhea (moderate certainty).

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
OR 3.26 [1.72, 6.19]
6 studies · 503 participants
Moderate

Intervention not reported

Vomiting · Patients with neurological conditions associated with rarer dementias

The intervention probably leads to higher vomiting (moderate certainty).

1 finding from 1 review

Cholinesterase inhibitors for rarer dementias associated with neurological conditions 2015 · Cochrane Headline outcomes only
OR 5.76 [1.67, 19.87]
3 studies · 374 participants
Moderate