Findings

What do systematic reviews say?

1,187 questions · 1,248 findings · 108 reviews · Stroke

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No studies found 275 · 22%GRADE not reported 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Intervention not reported

Intracranial haemorrhages · people with atrial fibrillation deemed eligible for long‐term anticoagulant treatment

The intervention leads to lower intracranial haemorrhages (high certainty).

1 finding from 1 review

Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial… 2018 · Cochrane Headline outcomes only
OR 0.5 [0.42, 0.59]
12 studies · 66259 participants
High

Intervention not reported

All‐cause deaths · people with atrial fibrillation deemed eligible for long‐term anticoagulant treatment

The intervention probably leads to lower all‐cause deaths (moderate certainty).

1 finding from 1 review

Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial… 2018 · Cochrane Headline outcomes only
OR 0.89 [0.83, 0.95]
10 studies · 65624 participants
Moderate

Educational or behavioural interventions for patients vs usual care

Systolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1398 participants
Moderate

Organisational interventions vs usual care

Blood pressure target achievement · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

Organisational interventions probably leads to higher blood pressure target achievement compared with usual care (moderate certainty).

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
OR 1.44 [1.09, 1.9]
13 studies · 23631 participants
Moderate

Organisational interventions vs usual care

Medication adherence (continuous) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 5384 participants
Low

Organisational interventions vs usual care

LDL‐cholesterol · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1008 participants
Moderate

Organisational interventions vs usual care

HbA1c (%) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 554 participants
Low

Organisational interventions vs usual care

Body‐mass index (BMI) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1089 participants
Low

Educational or behavioural interventions for patients vs usual care

Diastolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1398 participants
Moderate

Educational or behavioural interventions for patients vs usual care

Blood pressure target achievement · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

Educational or behavioural interventions for patients showed no clear difference in blood pressure target achievement compared with usual care (moderate certainty).

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
OR 1.34 [0.7, 2.59]
3 studies · 266 participants
Moderate

Educational or behavioural interventions for patients vs usual care

Medication adherence (continuous) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 33762 participants
Low

Educational or behavioural interventions for patients vs usual care

LDL‐cholesterol · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 495 participants
Moderate

Educational or behavioural interventions for patients vs usual care

HbA1c (%) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Low

Educational or behavioural interventions for patients vs usual care

Body‐mass index (BMI) · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
Moderate

Organisational interventions vs usual care

Systolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 17490 participants
Moderate

Organisational interventions vs usual care

Diastolic blood pressure · The trials included a total of 33,840 participants with cerebrovascular disease. The mean or median age of participants ranged from 60…

1 finding from 1 review

Interventions for improving modifiable risk factor control in the secondary prevention of stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 17178 participants
Moderate

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Functional outcomes

Percutaneous vascular interventions showed no clear difference in good functional outcome (mRS score 0‐2) compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review

Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
RR 1.01 [0.82, 1.25]
3 studies · 443 participants
Low

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Death

Percutaneous vascular interventions showed no clear difference in death compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review

Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
RR 1.34 [0.84, 2.14]
3 studies · 443 participants
Low

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Symptomatic intracranial haemorrhage at

Percutaneous vascular interventions showed no clear difference in symptomatic intracranial haemorrhage within first 14 days compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review

Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
RR 0.99 [0.5, 1.95]
4 studies · 450 participants
Low

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Vascular status (recanalisation rate)

The review found no eligible studies for this question.

1 finding from 1 review

Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found