Findings

What do systematic reviews say?

1,495 questions · 1,554 findings · 140 reviews · Heart

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No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Intervention not reported

RVX (high dose, 10 mg to 20 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1542 participants
Very low

Intervention not reported

RVX (low dose, 2.5 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1399 participants
Low

Intervention not reported

DAB (low dose, 110 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1962 participants
Low

Intervention not reported

DAB (high dose, 150 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1527 participants
Low

Intervention not reported

APX vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 4930 participants
Low

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Outcomes (up to 30 days' · adults with severe aortic stenosis who are at a low surgical risk.

The review found no eligible studies for this question.

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transcatheter aortic valve implantation vs surgical aortic valve replacement

All‐cause mortality · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in all‐cause mortality compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
RR 0.69 [0.33, 1.44]
4 studies · 2818 participants
Moderate

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Stroke · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in stroke compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
RR 0.73 [0.42, 1.25]
4 studies · 2818 participants
Moderate

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Patient readmissions · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in rehospitalisation compared with surgical aortic valve replacement (low certainty).

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
RR 0.64 [0.39, 1.06]
2 studies · 2468 participants
Low

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Myocardial infarction · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in myocardial infarction compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
RR 0.82 [0.42, 1.58]
3 studies · 2748 participants
Moderate

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Cardiac mortality · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in cardiac death compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
RR 0.71 [0.32, 1.56]
4 studies · 2818 participants
Moderate

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Length of hospital stay · adults with severe aortic stenosis who are at a low surgical risk.

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Permanent pacemaker implantation · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation probably leads to higher permanent pacemaker implantation compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people… 2019 · Cochrane Headline outcomes only
RR 3.65 [1.5, 8.87]
3 studies · 2683 participants
Moderate

Mechanical chest compressions vs manual chest compressions

Survival to hospital discharge with good neurological function · people suffering cardiac arrest

1 finding from 1 review

Mechanical versus manual chest compressions for cardiac arrest 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 7587 participants
Moderate

Mechanical chest compressions vs manual chest compressions

Survival to hospital discharge · people suffering cardiac arrest

1 finding from 1 review

Mechanical versus manual chest compressions for cardiac arrest 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 8067 participants
Moderate

Mechanical chest compressions vs manual chest compressions

Return of spontaneous circulation · people suffering cardiac arrest

1 finding from 1 review

Mechanical versus manual chest compressions for cardiac arrest 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 11771 participants
Low

Mechanical chest compressions vs manual chest compressions

Survival to hospital admission · people suffering cardiac arrest

1 finding from 1 review

Mechanical versus manual chest compressions for cardiac arrest 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 7224 participants
Moderate

Mechanical chest compressions vs manual chest compressions

Sternal or rib fractures · people suffering cardiac arrest

1 finding from 1 review

Mechanical versus manual chest compressions for cardiac arrest 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 7469 participants
Low

Mechanical chest compressions vs manual chest compressions

Haemothorax or pneumothorax · people suffering cardiac arrest

1 finding from 1 review

Mechanical versus manual chest compressions for cardiac arrest 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 7316 participants
Low

Mechanical chest compressions vs manual chest compressions

Internal abdominal organ injury · people suffering cardiac arrest

1 finding from 1 review

Mechanical versus manual chest compressions for cardiac arrest 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 7337 participants
Low