Findings

What do systematic reviews say?

1,444 questions · 1,518 findings · 135 reviews · Infectious Diseases

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No studies found 135 · 8.9%GRADE not reported 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%

Vitamin D vs placebo

All‐cause mortality · adults with HIV infection

It is very uncertain whether vitamin D changes mortality compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
RR 1.15 [0.65, 2.02]
1 study · 131 participants
Very low

Vitamin D vs placebo

Morbidity · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Vitamin D vs placebo

CD4 cell count · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 288 participants
Low

Vitamin D vs placebo

Viral load · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Very low

Vitamin D vs placebo

Change in 25(OH) vitamin D concentrations (ng/mL) · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 299 participants
Moderate

Zinc vs placebo

All‐cause mortality · adults with HIV infection

It is very uncertain whether zinc changes mortality compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
RR 1.24 [0.53, 2.86]
3 studies · 433 participants
Very low

Zinc vs placebo

Rate of diarrhoea · adults with HIV infection

It is very uncertain whether zinc changes rate of diarrhoea compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
OR 0.4 [0.18, 0.87]
1 study · 231 participants
Very low

Zinc vs placebo

Change in CD4 count · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 431 participants
Low

Zinc vs placebo

Change in viral load · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 400 participants
Low

Multiple micronutrients vs placebo

Hospital admissions · adults with HIV infection

It is very uncertain whether multiple micronutrients changes hospital admissions compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
RR 0.86 [0.61, 1.22]
2 studies · 881 participants
Very low

Zinc vs placebo

Change in blood zinc concentrations · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 484 participants
Moderate

Selenium vs placebo

All‐cause mortality · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selenium vs placebo

Hospital admissions · adults with HIV infection

It is very uncertain whether selenium changes hospital admissions compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
RR 0.4 [0.21, 0.75]
1 study · 186 participants
Very low

Selenium vs placebo

Change in CD4 count · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1187 participants
Low

Selenium vs placebo

Change in viral load · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 439 participants
Low

Selenium vs placebo

Change in selenium concentrations (µg/L) · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 527 participants
Low

Multiple micronutrients vs placebo

CD4 cell count · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1581 participants
Low

Multiple micronutrients vs placebo

Viral load · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 840 participants
Moderate

Multiple micronutrients vs placebo

Nutritional status · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1007 participants
Very low

Vitamin A vs placebo

All‐cause mortality · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported