Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Celecoxib vs NSAIDs

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Total number of withdrawals · patients with rheumatoid arthritis

Celecoxib probably leads to lower total withdrawals; compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs placebo

Pain A 0 t o 100 visual or numerical scale, where 0 equals no pain at all and 100 is the worst pain imaginable · patients with rheumatoid arthritis
1 finding from 1 review

Celecoxib vs placebo

Cardiovascular events (myocardial infarction, stroke) · patients with rheumatoid arthritis
1 finding from 1 review

Celecoxib vs placebo

Incidence of gastroduodenal ulcers ≥ 3 mm · patients with rheumatoid arthritis

Celecoxib showed no clear difference in incidence of gastroduodenal ulcers ≥ 3 mm compared with placebo (low certainty).

1 finding from 1 review

Celecoxib vs placebo

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Celecoxib vs placebo

Total number of withdrawals · patients with rheumatoid arthritis

Celecoxib may leads to lower total withdrawals; compared with placebo (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Pain A 0 t o 100 visual or numerical scale, where 0 equals no pain at all and 100 is the worst pain imaginable · patients with rheumatoid arthritis
1 finding from 1 review

Bisphosphonates vs control

Incident nonvertebral fractures Radiographic · adults with GIOP

Bisphosphonates showed no clear difference in incident nonvertebral fractures Radiographic compared with control (low certainty).

1 finding from 1 review