Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,187 questions · 1,248 findings · 108 reviews · Stroke

No studies found 275 · 22%GRADE not reported 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Calcium antagonists vs placebo

Death or dependency at end of · people with acute ischemic stroke

Calcium antagonists showed no clear difference in death or dependency at end of compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Death at the end of · people with acute ischemic stroke

Nimodipine showed no clear difference in death at the end of compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Recurrence of stroke at the end of · people with acute ischemic stroke

Nimodipine showed no clear difference in recurrence of stroke at the end of compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Adverse events during treatment period · people with acute ischemic stroke

Nimodipine showed no clear difference in adverse events during treatment period compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Hypotension · people with acute ischemic stroke

Nimodipine showed no clear difference in hypotension during treatment period compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Systolic blood pressure · people with acute ischemic stroke

Nimodipine showed no clear difference in mean systolic blood pressure during or at end of treatment compared with placebo (low certainty).

1 finding from 1 review

Flunarizine vs placebo

Death or dependency at end of · people with acute ischemic stroke

Flunarizine showed no clear difference in death or dependency at end of compared with placebo (low certainty).

1 finding from 1 review

Flunarizine vs placebo

Death at the end of treatment · people with acute ischemic stroke

Flunarizine showed no clear difference in death at the end of treatment compared with placebo (low certainty).

1 finding from 1 review

Flunarizine vs placebo

Recurrence of stroke at the end of · people with acute ischemic stroke

Flunarizine showed no clear difference in recurrence of stroke at the end of compared with placebo (low certainty).

1 finding from 1 review

Flunarizine vs placebo

Adverse events during treatment period · people with acute ischemic stroke

Flunarizine may leads to higher adverse events during treatment period compared with placebo (low certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Death at the end of treatment · people with acute ischemic stroke

Calcium antagonists showed no clear difference in death at the end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Isradipine vs placebo

Death or dependency at end of · people with acute ischemic stroke

Isradipine showed no clear difference in death or dependency at end of compared with placebo (low certainty).

1 finding from 1 review

Isradipine vs placebo

Death at the end of · people with acute ischemic stroke

Isradipine showed no clear difference in death at the end of compared with placebo (low certainty).

1 finding from 1 review