Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

NSAIDs vs placebo

Relief of pain · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID probably leads to higher adequate pain relief as reported by the woman (5 to 8 hours) compared with placebo (moderate certainty).

1 finding from 1 review

NSAIDs vs opioid

Maternal adverse events (6 to 8 hours) · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID may leads to lower maternal adverse events (6 to 8 hours) compared with opioid (low certainty).

1 finding from 1 review

Opioids vs placebo

Relief of pain · women who have given birth vaginally, requiring analgesia for after‐birth pains.

Opioid showed no clear difference in adequate pain relief as reported by the woman (5 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

Opioids vs placebo

Need for additional pain relief (6 to 8 hours) · women who have given birth vaginally, requiring analgesia for after‐birth pains.

Opioid may leads to lower need for additional pain relief (6 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

Opioids vs placebo

Maternal adverse events (6 to 8 hours) · women who have given birth vaginally, requiring analgesia for after‐birth pains.

Opioid showed no clear difference in maternal adverse events (6 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Additional pain relief · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID may leads to lower need for additional pain relief (5 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review