Neurological function improvement: lower‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1612(5 RCTs) · patients with newly diagnosed multiple brain metastases
Altered WBRT fractionation schedules probably leads to higher neurological function improvement: lower‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).
1 finding from 1 review
OR 1.74 [1.06, 2.84]
Studies not reported
Moderate
Neurological function improvement: higher‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1480(4 RCTs) · patients with newly diagnosed multiple brain metastases
Altered WBRT fractionation schedules showed no clear difference in neurological function improvement: higher‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).
1 finding from 1 review
OR 1.14 [0.92, 1.42]
Studies not reported
Moderate
Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases
WBRT with radiosensitisers (radiosen) showed no clear difference in overall survivalNo. of participants: 2631(8 RCTs) compared with WBRT alone (moderate certainty).
1 finding from 1 review
HR 1.05 [0.99, 1.12]
Studies not reported
Moderate
Intervention not reported
Progression of CIN to a higher grade of CIN · women with CIN 2 or CIN 3
It is very uncertain whether the intervention changes progression of CIN to a higher grade of CIN (very low certainty).
1 finding from 1 review
RR 0.54 [0.06, 5.24]
25 participants
Very low
Intervention not reported
Partial or complete regression of CIN 2 or CIN 3 · women with CIN 2 or CIN 3
The intervention showed no clear difference in partial or complete regression of CIN 2 or CIN 3 (moderate certainty).
1 finding from 1 review
RR 1.45 [0.93, 2.27]
132 participants
Moderate
Intervention not reported
Complete regression of CIN 2 or CIN 3 · women with CIN 2 or CIN 3
The intervention showed no clear difference in complete regression of CIN 2 or CIN 3 (moderate certainty).
1 finding from 1 review
RR 1.31 [0.65, 2.67]
116 participants
Moderate
All‐cause mortality · People undergoing radiation therapy for head and neck cancer
Hyperbaric oxygen leads to lower mortality compared with air breathing to enhance the effectiveness of radiotherapy (high certainty).
1 finding from 1 review
Metastasis · People undergoing radiotherapy for uterine cervical cancer
Hyperbaric oxygen showed no clear difference in metastasis compared with air breathing (high certainty).
1 finding from 1 review
Quality of life ‐ not reported · People undergoing radiotherapy for uterine cervical cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects · People undergoing radiotherapy for uterine cervical cancer
Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).
1 finding from 1 review
Mortality with urinary bladder cancer · People with any one of a mixed group of cancers
Hyperbaric oxygen showed no clear difference in mortality with urinary bladder cancer compared with air breathing (high certainty).
1 finding from 1 review
Failure of local tumour control ‐ not reported · People with any one of a mixed group of cancers
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Local recurrence · People with any one of a mixed group of cancers
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Metastases with urinary bladder cancer · People with any one of a mixed group of cancers
Hyperbaric oxygen showed no clear difference in metastases with urinary bladder cancer compared with air breathing (moderate certainty).
1 finding from 1 review
Quality of life ‐ not reported · People with any one of a mixed group of cancers
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects · People with any one of a mixed group of cancers
Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).
1 finding from 1 review
Failure of local tumour control ‐ not reported · People undergoing radiation therapy for head and neck cancer
Hyperbaric oxygen probably leads to lower failure of local tumour control (local control) compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).
1 finding from 1 review
Local recurrence · People undergoing radiation therapy for head and neck cancer
Hyperbaric oxygen leads to lower local recurrence (recurrence ) compared with air breathing to enhance the effectiveness of radiotherapy (high certainty).
1 finding from 1 review
Metastasis · People undergoing radiation therapy for head and neck cancer
Hyperbaric oxygen showed no clear difference in metastasis compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).
1 finding from 1 review
Quality of life ‐ not reported · People undergoing radiation therapy for head and neck cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found