Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,187 questions · 1,248 findings · 108 reviews · Stroke

No studies found 275 · 22%GRADE not reported 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Citicoline vs standard methods versus placebo

Disability or dependence in daily activities Patients with moderate or lower degree of disability or dependence (according to < 3 scores in the modified Rankin scale) lower scores indicate better outcome · people with acute ischemic stroke

Citicoline showed no clear difference in disability or dependence in daily activities Patients with moderate… compared with placebo or standard treatment (low certainty).

1 finding from 1 review

Citicoline vs standard methods versus placebo

Functional recoveryPatients with scores in the Barthel Index ≥ 95 points · people with acute ischemic stroke

Citicoline showed no clear difference in functional recoveryPatients with scores in the Barthel Index ≥ 95… compared with placebo or standard treatment (low certainty).

1 finding from 1 review

Citicoline vs standard methods versus placebo

Neurological functionPatients with minor impairment (according to ≤ 1 scores in the National Institutes of Health Stroke Scale) · people with acute ischemic stroke

Citicoline showed no clear difference in neurological functionPatients with minor impairment (according to ≤… compared with placebo or standard treatment (low certainty).

1 finding from 1 review