Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,494 questions · 1,521 findings · 132 reviews · Hepato-Biliary

No studies found 303 · 19.9%GRADE not reported 39 · 2.6%Very low 876 · 57.6%Low 216 · 14.2%Moderate 65 · 4.3%High 22 · 1.4%

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ interferon‐beta versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐beta versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ MTH‐68/B vaccine versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ MTH‐68/B vaccine versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ pegylated interferon‐alpha plus ribavirin… compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Adverse events (proportion) ‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Adverse events (number) ‐ interferon‐beta versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐beta versus no intervention compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

All‐cause mortality · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes all‐cause mortality compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

Serious adverse events · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes serious adverse events compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

Rebleeding · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes variceal rebleeding rate compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

Encephalopathy · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes encephalopathy compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

Ascites · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes ascites compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

Any re‐intervention · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes any re‐intervention compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review