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What do systematic reviews say?

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Evidence found and GRADE certainty

2,234 questions · 2,325 findings · 216 reviews · Airways

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No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%

Sublingual immunotherapy vs control

Serious adverse events Weighted mean duration of studies: 49 weeks · people with asthma

Sublingual immunotherapy showed no clear difference in serious adverse events Weighted mean duration of studies: 56 weeks compared with control (moderate certainty).

1 finding from 1 review

Sublingual immunotherapy vs control

Exacerbation requiring OCS Weighted mean duration of studies: 25 weeks · people with asthma

It is very uncertain whether sublingual immunotherapy changes exacerbation requiring OCS Weighted mean duration of studies: 58 weeks compared with control (very low certainty).

1 finding from 1 review

Sublingual immunotherapy vs control

All adverse events Weighted mean duration of studies: 60 weeks** · people with asthma

Sublingual immunotherapy leads to higher all adverse events Weighted mean duration of studies: 62 weeks** compared with control (high certainty).

1 finding from 1 review

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

Exacerbations · patients with chronic obstructive pulmonary disease

PPI plus usual care may leads to lower exacerbation rate (participants with one or more) study duration: 12… compared with usual care alone or chronic obstructive pulmonary disease (low certainty).

1 finding from 1 review