Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,444 questions · 1,518 findings · 135 reviews · Infectious Diseases

No studies found 135 · 8.9%GRADE not reported 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%

Doxycycline vs tetracycline

Treatment failure · adults with scrub typhus

It is very uncertain whether doxycycline changes treatment failure compared with tetracycline (very low certainty).

1 finding from 1 review

Rifampicin vs doxycycline

Resolution of fever within 48 hours · adults with scrub typhus

It is very uncertain whether rifampicin changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Doxycycline vs tetracycline

Resolution of fever within 48 hours · adults with scrub typhus

Doxycycline showed no clear difference in resolution of fever within 48 hours compared with tetracycline (low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Treatment failure · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes treatment failure compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 48 hours · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review