Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,139 questions · 1,173 findings · 89 reviews · Neuromuscular

No studies found 302 · 25.7%GRADE not reported 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Plasma exchange vs sham exchange or supportive treatment

Recurrence of hyperthyroidism (relapse) [measured by serum thyroid hormone levels above the normal range after withdrawal of methimazole or end of radioiodine treatment] · patients with Guillain‐Barré syndrome

Plasma exchange probably leads to higher relapses at 1 year compared with sham exchange or supportive treatment (moderate certainty).

1 finding from 1 review

Intervention not reported

Change in disability after one year · people with chronic inflammatory demyelinating polyradiculoneuropathy

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Change in impairment after 12 weeks (excluding those who did not complete the study) NIS score (range 0 to 280) · people with chronic inflammatory demyelinating polyradiculoneuropathy
1 finding from 1 review

Intervention not reported

Change in impairment after 12 weeks (including those who did not complete the study) NIS (range 0 to 280) · people with chronic inflammatory demyelinating polyradiculoneuropathy
1 finding from 1 review

Intervention not reported

Number of participants improved after 12 weeks (excluding those who did not complete the study) NIS score (range 0 to 280) · people with chronic inflammatory demyelinating polyradiculoneuropathy

It is very uncertain whether the intervention changes number of participants improved after 12 weeks (excluding those who… (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants improved after 12 weeks (including those who did not complete the study) NIS (range 0 to 280) · people with chronic inflammatory demyelinating polyradiculoneuropathy

It is very uncertain whether the intervention changes number of participants improved after 12 weeks (including those who… (very low certainty).

1 finding from 1 review

Monthly pulsed high‐dose dexamethasone vs prednisolone

≥ 1 point improvement on INCAT disability score at 12 months · patients with chronic inflammatory demyelinating polyradiculoneuropathy

Monthly pulsed high‐dose dexamethasone may leads to higher ≥ 1 point improvement on INCAT disability score at 12 months compared with oral prednisolone (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review