Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Opioids vs other analgesics

Episodes of apnea · procedural pain in neonates

It is very uncertain whether opioids changes episodes of apnea—during the procedure compared with other analgesics (very low certainty).

1 finding from 1 review

Opioids vs other analgesics

Episodes of apnea—after the procedure · procedural pain in neonates

It is very uncertain whether opioids changes episodes of apnea—after the procedure compared with other analgesics (very low certainty).

1 finding from 1 review

Opioids vs other analgesics

Hypotension · procedural pain in neonates

It is very uncertain whether opioids changes hypotension compared with other analgesics (very low certainty).

1 finding from 1 review

Opioids vs other analgesics

Parent satisfaction with care provided in the NICU—not reported · procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Opioids vs no treatment/placebo

Any harms ‐ severe apnea requiring resuscitation · procedural pain in neonates

It is very uncertain whether opioids changes any harms ‐ severe apnea requiring resuscitation compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Opioids vs no treatment/placebo

Episodes of bradycardia · procedural pain in neonates

It is very uncertain whether opioids changes episodes of bradycardia compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Treatment failure · preterm infants receiving nasal CPAP

Bubble may leads to lower treatment failure compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Mortality before hospital discharge · preterm infants receiving nasal CPAP

Bubble showed no clear difference in all‐cause mortality before hospital discharge compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Pneumothorax · preterm infants receiving nasal CPAP

Bubble showed no clear difference in pneumothorax compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Moderate‐severe nasal injury · preterm infants receiving nasal CPAP

Bubble probably leads to higher moderate‐severe nasal injury compared with ventilator or Infant Flow Driver nasal continuous positive airway… (moderate certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Bronchopulmonary dysplasia · preterm infants receiving nasal CPAP

Bubble showed no clear difference in bronchopulmonary dysplasia compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review