Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

671 questions · 731 findings · 61 reviews · Drugs and Alcohol

No studies found 57 · 7.8%GRADE not reported 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%

Baclofen vs placebo

Relapse: return to any drinking at end of treatment · alcohol use disorder

Summary of findings table ‐ Baclofen probably leads to lower relapse: return to any drinking at end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Baclofen vs acamprosate

Dropout · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts at end of treatment compared with acamprosate (very low certainty).

1 finding from 1 review

Baclofen vs acamprosate

Dropouts due to adverse events · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts due to adverse events compared with acamprosate (very low certainty).

1 finding from 1 review

Baclofen vs naltrexone

Relapse: return to any drinking at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes relapse: return to any drinking at end of treatment compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen vs naltrexone

Adverse events: number of participants with ≥ 1 adverse event at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes adverse events: number of participants with ≥ 1 adverse event at end… compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen vs naltrexone

Dropout · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts at end of treatment compared with naltrexone (very low certainty).

1 finding from 1 review