Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

762 questions · 830 findings · 43 reviews · Orthodontics

No studies found 186 · 22.4%GRADE not reported 410 · 49.4%Very low 122 · 14.7%Low 79 · 9.5%Moderate 30 · 3.6%High 3 · 0.4%

NSAID (systemic) vs paracetamol

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).

3 findings from 1 review

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Gum health: bleeding on probing (Papilla Bleeding Index) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in gum health: bleeding on probing (Papilla Bleeding Index) compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Bonded molar tubes (attached with adhesive) vs Molar bands (cemented, e.g. with glass ionomer cement)

Decalcification · Participants with full arch fixed orthodontic appliance(s) with molar tubes bonded to first or second permanent molars; excludes prior…

Bonded molar tubes (attached with adhesive) led to higher decalcification (participant level) compared with molar bands (cemented, e.g. with glass ionomer cement); GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Gum health: gingival recession (six-point probing) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in gum health: gingival recession (six-point probing) compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Patient response: total discomfort score (pain, difficulty eating, brushing, speaking, bad taste) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in patient response: total discomfort score (pain, difficulty eating,… compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review

Topical NSAID (ketoprofen chewing gum) vs Local anaesthetic (benzocaine chewing gum)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

It is very uncertain whether topical NSAID (ketoprofen chewing gum) changes pain intensity (VAS 0-100 mm) compared with local anaesthetic (benzocaine chewing gum) (very low certainty).

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Aesthetics: canine rated as abnormal tooth inclination · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in aesthetics: canine rated as abnormal tooth inclination compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Patient response: moderate or severe pain at 1 day postoperative · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in patient response: moderate or severe pain at 1 day postoperative compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Treatment time: duration of orthodontic treatment (placement to removal of fixed appliances) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in treatment time: duration of orthodontic treatment (placement to… compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review