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What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

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No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Open surgical excision vs eccentric exercises

Participant global assessment of success (People who perceived their pain as none) · adult participants with patellar tendinopathy

Open surgical excision showed no clear difference in participant global assessment of success (People who perceived their… compared with eccentric exercises (low certainty).

1 finding from 1 review

Paracetamol vs placebo

Mean change in pain (0–100 scale) Short term (3–12 weeks), where 0 = no pain · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in mean change in pain (0–100 scale) Short term (3–12 weeks), where 0 =… compared with placebo (high certainty).

1 finding from 1 review

Paracetamol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in withdrawals due to adverse events 24 weeks compared with placebo (moderate certainty).

1 finding from 1 review

Paracetamol vs placebo

Total adverse events: number experiencing 24 weeks · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in total adverse events: number experiencing 24 weeks compared with placebo (high certainty).

1 finding from 1 review