Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,281 questions · 1,361 findings · 120 reviews · Developmental, Psychosocial and Learning Problems

No studies found 286 · 21%GRADE not reported 61 · 4.5%Very low 381 · 28%Low 381 · 28%Moderate 228 · 16.8%High 24 · 1.8%

BoNT‐A vs usual care or physiotherapy

Adverse events · children with CP

The review found no eligible studies for this question.

3 findings from 1 review

BoNT‐A vs usual care or physiotherapy

Gait assessment ‐ not measured · children with CP

The review found no eligible studies for this question.

2 findings from 1 review

BoNT‐A vs sham

Observational gait analysis (improvement) · children with CP

BoNT‐A probably leads to higher observational gait analysis (improvement) compared with placebo or sham (moderate certainty).

2 findings from 1 review

BoNT‐A vs sham

Function · children with CP
3 findings from 1 review

BoNT‐A vs sham

Range of motion (passive ankle dorsiflexion) · children with CP
3 findings from 1 review

BoNT‐A vs sham

Satisfaction · children with CP
3 findings from 1 review

BoNT‐A vs sham

Spasticity (ankle plantarflexors) · children with CP
3 findings from 1 review

BoNT‐A vs sham

Adverse events · children with CP

BoNT‐A showed no clear difference in adverse events compared with placebo or sham (moderate certainty).

3 findings from 1 review

BoNT‐A vs sham

Instrumented gait analysis (kinematics) (not measured) · children with CP

The review found no eligible studies for this question.

2 findings from 1 review

BoNT‐A vs serial casting

Instrumented gait analysis (peak ankle dorsiflexion in stance) · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Observational gait analysis · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Function · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Satisfaction (not measured) · children with CP

The review found no eligible studies for this question.

3 findings from 1 review

BoNT‐A vs serial casting

Spasticity (ankle plantarflexors) · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Adverse events · children with CP

BoNT‐A showed no clear difference in adverse events compared with serial casting (low certainty).

3 findings from 1 review