Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

762 questions · 830 findings · 43 reviews · Orthodontics

No studies found 186 · 22.4%GRADE not reported 410 · 49.4%Very low 122 · 14.7%Low 79 · 9.5%Moderate 30 · 3.6%High 3 · 0.4%

Twin Block functional appliance vs Other functional appliances (Bionator, Herbst, R-appliance, Dynamax, Bite-Jumping)

Incidence of incisal trauma · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth

Number of visits to complete treatment · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth)

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Ibuprofen taken pre-emptively (about 1 hour before treatment) showed no clear difference in rescue analgesia compared with ibuprofen taken post-treatment; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Gum health: midbuccal gingival recession (mm) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in gum health: midbuccal gingival recession (mm) compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) probably leads to lower pain intensity (VAS 0-100 mm) compared with control (placebo or no treatment) (moderate certainty).

3 findings from 1 review

Open surgical exposure vs Closed surgical exposure

Probing pocket depth · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in gum health: periodontal probing depth compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

It is very uncertain whether ibuprofen taken pre-emptively (about 1 hour before treatment) changes pain intensity (VAS 0-100 mm) compared with ibuprofen taken post-treatment (very low certainty).

3 findings from 1 review

Open surgical exposure vs Closed surgical exposure

Complications or adverse effects · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
1 finding from 1 review

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Failure to complete orthodontic treatment due to pain · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Pain intensity (0‐10cm visual analogue scale) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in patient response: pain/soreness score (visual analogue scale 1 to 10) compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Treatment time: time from surgical exposure to eruption/bonding a bracket · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure led to lower treatment time: time from surgical exposure to eruption/bonding a… compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Discomfort/pain · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Aesthetics: canine rated as abnormal position in the dental arch · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in aesthetics: canine rated as abnormal position in the dental arch compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

One type of adhesive used to bond molar tubes (chemically-cured composite, light-cured composite, conventional glass ionomer, poly-acid modified composite/compomer, or resin-modified glass ionomer) vs Any other type of adhesive used to bond molar tubes

First-time bond failure · Participants with full arch fixed orthodontic appliance(s) with molar tubes bonded to first or second permanent molars; excludes prior…

The review found no eligible studies for this question.

1 finding from 1 review