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What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

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No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Exercise vs no intervention

Adverse effects associated with exercises Exercise programme duration: range 3 to 24 weeks · adults with ankylosing spondylitis

It is very uncertain whether exercise programmes changes adverse effects associated with exercises Exercise programme… compared with no intervention (very low certainty).

1 finding from 1 review

Exercise vs no intervention

Withdrawals due to adverse events · adults with ankylosing spondylitis

Exercise programmes showed no clear difference in withdrawals because of adverse events Exercise programme duration:… compared with no intervention (low certainty).

1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs non‐surgical treatment

Quality of life · Adults with symptomatic mild to moderate knee osteoarthritis defined as knee pain and radiographic evidence of non‐end stage…

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Disease response · psoriatic arthritis

Methotrexate may leads to higher disease response compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Health‐related quality of life ‐ not reported · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Change in radiographic progression ‐ not measured · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

SAEs · psoriatic arthritis

Methotrexate showed no clear difference in serious adverse events (SAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · psoriatic arthritis

Methotrexate showed no clear difference in withdrawals due to adverse events (WAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs other DMARDs

Disease response (leflunomide) · psoriatic arthritis

It is very uncertain whether methotrexate changes disease response (leflunomide) compared with other DMARDs (very low certainty).

1 finding from 1 review