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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

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No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Intervention not reported

Fractures · individuals with osteoporotic vertebral fracture

It is very uncertain whether the intervention changes fractures (very low certainty).

1 finding from 1 review

Intervention not reported

Falls · individuals with osteoporotic vertebral fracture

It is very uncertain whether the intervention changes falls (very low certainty).

1 finding from 1 review

Intervention not reported

Pain Scale: VAS (0 to 10), pain subscale of Functional Status Index (0 to 10) Higher score indicates greater pain levels · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Intervention not reported

Physical performance: self‐report questionnaires Physical function subscale from the QUALEFFO‐41 Scale from 0 to 100 Lower scores indicate better physical function · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Intervention not reported

Disease‐specific quality of life QUALEFFO‐41 total score Scale from 0 to 100 Lower scores indicate better quality of life · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Proportion participants that switched to another biologic due to loss of response ‐ not measured · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

The review found no eligible studies for this question.

1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Proportion of participants with minimal radiographic progression · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF discontinuation leads to higher proportion participants with minimal radiographic progression compared with anti‐TNF continuation (high certainty).

1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Number of serious adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

It is very uncertain whether anti‐TNF discontinuation changes number of serious adverse events compared with anti‐TNF continuation (very low certainty).

1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Withdrawals due to adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF discontinuation showed no clear difference in withdrawals due to adverse events compared with anti‐TNF continuation (moderate certainty).

1 finding from 1 review

Anti‐TNF disease activity–guided dose tapering vs anti‐TNF continuation

Maintenance of clinical remission · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF disease activity–guided dose tapering showed no clear difference in proportion of participants with persistent remission compared with anti‐TNF continuation (high certainty).

1 finding from 1 review

Anti‐TNF disease activity–guided dose tapering vs anti‐TNF continuation

Proportion of participants switched to another biologic due to loss of response · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF disease activity–guided dose tapering showed no clear difference in proportion of participants switched to another biologic due to loss… compared with anti‐TNF continuation (low certainty).

1 finding from 1 review

Anti‐TNF disease activity–guided dose tapering vs anti‐TNF continuation

Proportion of participants with minimal radiographic progression · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF disease activity–guided dose tapering showed no clear difference in proportion of participants with minimal radiographic progression compared with anti‐TNF continuation (low certainty).

1 finding from 1 review