Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

962 questions · 1,000 findings · 69 reviews · Urology

No studies found 196 · 19.6%GRADE not reported 33 · 3.3%Very low 198 · 19.8%Low 354 · 35.4%Moderate 206 · 20.6%High 13 · 1.3%

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Late gastrointestinal RT toxicity ≥ Grade II RTOG/EORTC · clinically localized prostate cancer

It is very uncertain whether altered fraction schedules changes late gastrointestinal RT toxicity ≥ Grade II RTOG/EORTC compared with conventional fractionation (very low certainty).

1 finding from 1 review

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Late genitourinary RT toxicity ≥ Grade II RTOG/EORTC · clinically localized prostate cancer

Altered fraction schedules showed no clear difference in late genitourinary RT toxicity ≥ Grade II RTOG/EORTC compared with conventional fractionation (moderate certainty).

1 finding from 1 review

Robotic‐assisted laparoscopic vs open radical cystectomy

Positive margins assessed through pathological evaluation of cystectomy specimen · bladder cancer in adults

Robotic‐assisted laparoscopic showed no clear difference in positive margins assessed through pathological evaluation of… compared with open radical cystectomy (low certainty).

1 finding from 1 review