Findings

What do systematic reviews say?

996 questions · 1,049 findings · 79 reviews · Dementia and Cognitive Improvement

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No studies found 240 · 22.9%GRADE not reported 31 · 3%Very low 216 · 20.6%Low 253 · 24.1%Moderate 238 · 22.7%High 71 · 6.8%

Intervention not reported

Number suffering at least one adverse event · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
29 studies · 8033 participants
High

Intervention not reported

Number suffering at least one serious adverse event · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 6482 participants
High

Intervention not reported

Number suffering agitation as an adverse event · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 4395 participants
Moderate

Intervention not reported

Cognitive function (MMSE or ADAS‐cog+) · vascular dementia

1 finding from 1 review

Cerebrolysin for vascular dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 420 participants
Very low

Intervention not reported

Quality of life · vascular dementia

The review found no eligible studies for this question.

1 finding from 1 review

Cerebrolysin for vascular dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Caregiver burden · vascular dementia

The review found no eligible studies for this question.

1 finding from 1 review

Cerebrolysin for vascular dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Binary outcomes · vascular dementia

The review found no eligible studies for this question.

1 finding from 1 review

Cerebrolysin for vascular dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Improvement in cognitive function reported as responder rates (MMSE, ADAS‐cog+, and HDS) · vascular dementia

1 finding from 1 review

Cerebrolysin for vascular dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 338 participants
Very low

Intervention not reported

Improvement in global function reported as response rates (CIBIC+ and CGI) · vascular dementia

1 finding from 1 review

Cerebrolysin for vascular dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 379 participants
Very low

Intervention not reported

Non‐serious adverse events · vascular dementia

1 finding from 1 review

Cerebrolysin for vascular dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 379 participants
Very low

Single‐component hydration intervention vs control

Prevalence of delirium Not measured · people at risk of delirium in institutional long‐term care

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Multicomponent educational intervention vs control

Severity of delirium · preventing delirium in older people in institutional long‐term care

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Multicomponent educational intervention vs control

All‐cause mortality · preventing delirium in older people in institutional long‐term care

Multicomponent educational intervention showed no clear difference in mortality compared with control (moderate certainty).

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
RR 0.82 [0.5, 1.34]
1 study · 215 participants
Moderate

Multicomponent educational intervention vs control

Cognitive function · preventing delirium in older people in institutional long‐term care

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Multicomponent educational intervention vs control

Falls · preventing delirium in older people in institutional long‐term care

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Multicomponent educational intervention vs control

Hospital admissions · preventing delirium in older people in institutional long‐term care

Multicomponent educational intervention probably leads to lower hospital admissions compared with control (moderate certainty).

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
RR 0.67 [0.57, 0.79]
1 study · 494 participants
Moderate

Single‐component medication monitoring and adjustment intervention vs control

Prevalence of delirium · people at risk of delirium in institutional long‐term care

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Single‐component medication monitoring and adjustment intervention vs control

Incidence of delirium · people at risk of delirium in institutional long‐term care

Single‐component medication monitoring and adjustment intervention probably leads to lower incidence of delirium NH‐CAM compared with control (moderate certainty).

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
HR 0.42 [0.34, 0.51]
1 study · 7311 participants
Moderate

Single‐component medication monitoring and adjustment intervention vs control

Severity of delirium · people at risk of delirium in institutional long‐term care

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Single‐component medication monitoring and adjustment intervention vs control

All‐cause mortality · people at risk of delirium in institutional long‐term care

Single‐component medication monitoring and adjustment intervention showed no clear difference in mortality compared with control (moderate certainty).

1 finding from 1 review

Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
HR 0.88 [0.66, 1.17]
1 study · 9412 participants
Moderate