Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask (with frame internal fixation) showed no clear difference in wits appraisal compared with frankel III functional appliance; GRADE not reported.
1 finding from 1 review
Incidence of new ICLs (mean number of new lesions per subject) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
Patients developed on average about 2.29 new ICLs during fixed orthodontic treatment (95% CI 1.12-3.46; very low certainty; very high heterogeneity).
1 finding from 1 review
White spot lesion incidence, area, and depth · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
GC Ortho Connect had more frequent, larger, and deeper WSLs, with certainty not graded.
1 finding from 1 review
Group 3 (GC Ortho Connect) showed a significantly higher incidence than both groups (p < 0.001). Group 3 (GC Ortho Connect) also had larger lesion areas and deeper lesions compared to other groups (p < 0.001).
1 study · 75 participants
GRADE not reported
Prevalence of ICLs (mean number of lesions per subject) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
Patients had on average about 2.24 ICLs per subject during/after fixed orthodontic treatment (95% CI 1.79-2.70; very low certainty; very high heterogeneity).
1 finding from 1 review
Fluoride ion release · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, the commercial RMGIC Fuji Ortho LC showed significant fluoride release up to 6 months in a single study (ungraded).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review
Arun 1994 (n=60): ANB data not usable (no SDs); Mann-Whitney P<0.001 benefit for mandibular headgear. Effect ~0.5 degrees, probably not clinically significant.
1 study · 60 participants
GRADE not reported
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Reverse Twin Block with lip pads and rapid maxillary expander (RME) led to higher ANB compared with untreated control (no treatment); GRADE not reported.
1 finding from 1 review
White spot lesion area · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no significant difference in WSL area, with certainty not graded.
1 finding from 1 review
There was no significant difference in the WSL area between the two groups, with the mean WSL area measuring 161.3 mm2 in the Opal Seal group and 1361.2 mm2 in the conventional group.
1 study · 56 participants
GRADE not reported
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Reverse Forsus led to higher ANB compared with untreated control (no treatment); GRADE not reported.
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Non-surgical orthodontic treatment (any: facemask, chin cup, tandem… probably leads to higher overjet compared with no treatment (moderate certainty).
1 finding from 1 review
Enamel remineralization extent · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, n-ACP-containing orthodontic adhesives showed significant enamel remineralization versus control in both studies, but evidence is weak (only 2 studies; ungraded).
1 finding from 1 review
Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask led to higher wits appraisal compared with untreated control (no treatment); GRADE not reported.
1 finding from 1 review
Enamel remineralization / anti-demineralization extent · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, most bioactive glass-containing orthodontic adhesives (9 of 13 studies) showed significant enamel remineralization/anti-demineralization versus control, but the evidence is weak (predominantly high risk of bias, methodological heterogeneity, no meta-analysis; ungraded).
1 finding from 1 review
Out of 13 studies that evaluated bioactive glass particles/nanoparticles, 9 reported definitive statistically significant remineralization potential compared to control orthodontic adhesives [17, 21-24, 26-28, 31]; one…
13 studies
GRADE not reported
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Surgically-anchored orthodontic treatment (miniplates) may leads to higher overjet compared with untreated control (no treatment) (low certainty).
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask led to higher overjet compared with untreated control (no treatment); GRADE not reported.
3 findings from 1 review
MD 5.04 [4.29, 5.80]
2 studies · 92 participants
GRADE not reported
MD 1.30 [-0.16, 2.76]
1 study · 65 participants
Low
MD 2.50 [1.21, 3.79]
1 study · 63 participants
Moderate
Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) showed no clear difference in wits appraisal compared with facemask only; GRADE not reported.
1 finding from 1 review
Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Single-strand superelastic NiTi arch wire probably leads to lower alignment rate compared with coaxial superelastic NiTi arch wire (moderate certainty).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) showed no clear difference in ANB compared with reverse chin cup; GRADE not reported.
1 finding from 1 review
Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single triple-blinded RCT found the ACP-containing adhesive reduced enamel demineralization versus a conventional adhesive over 6 months (ungraded).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Tandem traction bow appliance led to higher ANB compared with untreated control (no treatment); GRADE not reported.
1 finding from 1 review