Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

67 questions · 67 findings · 8 reviews · Methodology

No studies found 15 · 22.4%GRADE not reported 0 · 0%Very low 22 · 32.8%Low 19 · 28.4%Moderate 8 · 11.9%High 3 · 4.5%

Intervention not reported

Retention [ · trial participants being followed up for data collection

The intervention showed no clear difference in retention [ (low certainty).

1 finding from 1 review

Risk‐based vs extensive on‐site monitoring

Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care

Risk‐based showed no clear difference in combined outcome of proportion of participants with major or… compared with extensive on‐site monitoring (moderate certainty).

1 finding from 1 review

Central and local monitoring only vs central and local monitoring with on‐site visits

Impact of the monitoring strategy on · clinical trials in all fields of health care

It is very uncertain whether central and local monitoring only changes impact of the monitoring strategy on compared with central and local monitoring with on‐site visits (very low certainty).

1 finding from 1 review