Findings

What do systematic reviews say?

1,501 questions · 1,558 findings · 115 reviews · Vascular

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No studies found 346 · 22.2%GRADE not reported 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

Intervention not reported

CVA ( · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Low

Intervention not reported

Major bleeding ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes major bleeding ( (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 0.25 [0.01, 4.9]
1 study · 70 participants
Very low

Intra‐arterial delivery vs intravenous delivery

30‐Day mortality · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Low

Intra‐arterial delivery vs intravenous delivery

Vessel patency ‐ radiological success ‐ complete (to end of treatment) · patients with < 30 days' limb ischaemiaa

Intra‐arterial delivery may leads to higher vessel patency ‐ radiological success ‐ complete (to end of treatment) compared with intravenous delivery (low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 13.22 [2.79, 62.67]
1 study · 40 participants
Low

Intra‐arterial delivery vs intravenous delivery

Duration of thrombolysis (to end of treatment) · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Very low

Intra‐arterial delivery vs intravenous delivery

CVA (up to 6 months) · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Very low

Intra‐arterial delivery vs intravenous delivery

Major bleeding · patients with < 30 days' limb ischaemiaa

It is very uncertain whether intra‐arterial delivery changes major bleeding (up to 6 months) compared with intravenous delivery (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 0.12 [0.01, 2.53]
1 study · 40 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Amputation · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

Valvuloplasty plus surgery of the superficial venous system vs surgery of the superficial venous system

Incidence and recurrence after healing of ulcers · people with non‐severe primary valvular incompetence

The review found no eligible studies for this question.

1 finding from 1 review

Surgery for deep venous insufficiency 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Valvuloplasty plus surgery of the superficial venous system vs surgery of the superficial venous system

Complications of surgery (2–10 years) · people with non‐severe primary valvular incompetence

1 finding from 1 review

Surgery for deep venous insufficiency 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 105 participants
Very low

Valvuloplasty plus surgery of the superficial venous system vs surgery of the superficial venous system

Clinical changes (CEAP classification scoring for clinical outcomes after surgery) (3 years) · people with non‐severe primary valvular incompetence

1 finding from 1 review

Surgery for deep venous insufficiency 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 208 participants
Low

Valvuloplasty plus surgery of the superficial venous system vs surgery of the superficial venous system

Health‐related quality of life (VAS, ranging from 0 (no problem) to 10 (most severe problem) for each of 10‐items, cumulated score) (10 years) · people with non‐severe primary valvular incompetence

1 finding from 1 review

Surgery for deep venous insufficiency 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Valvuloplasty plus surgery of the superficial venous system vs surgery of the superficial venous system

Discomfort/pain · people with non‐severe primary valvular incompetence

1 finding from 1 review

Surgery for deep venous insufficiency 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 75 participants
Very low

Foam sclerotherapy vs placebo

Cosmetic appearance · participants with varicose veinsa

1 finding from 1 review

Injection sclerotherapy for varicose veins 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 223 participants
Very low

Foam sclerotherapy vs foam sclerotherapy

QoL · participants with varicose veinsa

The review found no eligible studies for this question.

1 finding from 1 review

Injection sclerotherapy for varicose veins 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Foam sclerotherapy vs foam sclerotherapy

Persistence of symptoms · participants with varicose veinsa

The review found no eligible studies for this question.

1 finding from 1 review

Injection sclerotherapy for varicose veins 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Foam sclerotherapy vs foam sclerotherapy

Recurrent varicose veins · participants with varicose veinsa

Foam sclerotherapy showed no clear difference in recurrent varicose veins compared with foam sclerotherapy (low certainty).

1 finding from 1 review

Injection sclerotherapy for varicose veins 2021 · Cochrane Headline outcomes only
RR 0.91 [0.62, 1.32]
1 study · 148 participants
Low

Foam sclerotherapy vs liquid sclerotherapy

Cosmetic appearance · participants with varicose veinsa

1 finding from 1 review

Injection sclerotherapy for varicose veins 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 126 participants
Very low

Foam sclerotherapy vs liquid sclerotherapy

Complications ‐ DVT · participants with varicose veinsa

The review found no eligible studies for this question.

1 finding from 1 review

Injection sclerotherapy for varicose veins 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found