Findings

What do systematic reviews say?

1,501 questions · 1,558 findings · 115 reviews · Vascular

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No studies found 346 · 22.2%GRADE not reported 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

Heparin vs pentasaccharide

Major bleeding · people undergoing bariatric surgery

It is very uncertain whether heparin changes major bleeding compared with pentasaccharide (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
RR 1.7 [0.42, 6.92]
1 study · 198 participants
Very low

Intra‐arterial delivery vs intravenous delivery

30‐Day amputation‐free survival · patients with < 30 days' limb ischaemiaa

It is very uncertain whether intra‐arterial delivery changes 30‐Day amputation‐free survival compared with intravenous delivery (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 1.71 [0.4, 7.34]
1 study · 40 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

30‐Day mortality · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Vessel patency (at end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Stroke · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Major bleeding · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Amputation · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 164 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

30‐Day mortality · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Vessel patency (up to 30 days) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Intra‐arterial delivery vs intravenous delivery

Amputation · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Stroke · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Major bleeding · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Intervention not reported

30‐Day amputation‐free survival · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
GRADE not reported

Intervention not reported

Amputation ( · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
GRADE not reported

Intervention not reported

30‐Day mortality · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
GRADE not reported

Intervention not reported

Vessel patency ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes vessel patency ( (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 1.2 [0.39, 3.69]
1 study · 70 participants
Very low

Intervention not reported

Duration of thrombolysis ( · patients with less than 42 days' lower limb ischaemia

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Low