Findings

What do systematic reviews say?

3,556 questions · 10,375 findings · 429 reviews · All outcomes

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Antimicrobial coolant A (chlorhexidine) vs Distilled water coolant

Reduction in level of contamination in aerosols (CFU): chlorhexidine coolant vs distilled water during ultrasonic scaling · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether chlorhexidine coolant changes reduction in level of contamination in aerosols (CFU): chlorhexidine… compared with distilled water coolant (very low certainty).

1 finding from 1 review

Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
MD -124.00 [-135.78, -112.22]
1 study · 20 participants
Very low

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care

Duration of ICU stay · Critically ill patients (adults and children) receiving mechanical ventilation in ICU

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in duration of ICU stay compared with placebo or usual care (low certainty).

1 finding from 1 review

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
Follow-up: mean 1 month
MD -0.89 [-3.59, 1.82]
5 studies · 627 participants
Low

G allele of LTF rs1126478 vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under an allelic model (OR 1.41, 95% CI 0.48 to 4.13; ungraded).

1 finding from 1 review

The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes
Brazil; United States; European countries; China · Allelic model (G vs. A)
OR 1.41 [0.48, 4.13]
4 studies · 1802 participants
GRADE not reported

Bleaching vs No bleaching or alternative control

Colour disparity between carious and non-affected enamel · Permanent teeth with post-orthodontic or artificial white spot lesions

Bleaching may diminish colour disparities between carious and non-affected areas (very low certainty).

1 finding from 1 review

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes
Varied; 28 days in the RCT · clinical and laboratory settings
no estimate extracted
3 studies
GRADE not reported

Video modelling acclimatisation vs Acclimatisation in clinic (tell-show-do)

Successful LA/painless treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes
In advance of LA
Successful LA/painless treatment: included studies did not report on this outcome
Studies not reported
No studies found

Clindamycin + SRP vs SRP

Antimicrobial resistance · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Dexamethasone + nystatin + curcumin (adjunctive) vs Dexamethasone + nystatin + placebo

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
Amirchaghmaghi 2016: no benefit of adjunctive curcumin for pain (low to very low certainty collectively)
1 study
GRADE not reported

Ultrasonic bone removal vs Bur

Swelling (mean) · Adults with mandibular third molars requiring removal

Ultrasonic bone removal led to higher swelling (mean) compared with bur; GRADE not reported.

1 finding from 1 review

Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes
7 days · ultrasound vs bur
MD 0.37 [0.20, 0.54]
1 study · 26 participants
GRADE not reported

Laminar air flow with HEPA filter vs Without laminar flow or filter

Reduction in level of contamination in aerosols (CFU per cubic feet/min/patient) using Reyniers slit sampler 30 inches (76 cm) from floor · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether laminar air flow with HEPA filter changes reduction in level of contamination in aerosols (CFU per cubic… compared with without laminar flow or filter (very low certainty).

1 finding from 1 review

Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
MD -319.14 [-385.60, -252.68]
1 study · 50 participants
Very low

Rubber dam vs No rubber dam

Reduction in level of contamination in aerosols (CFU) during restorative procedures at operator's left ear (RCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

Rubber dam showed no clear difference in reduction in level of contamination in aerosols (CFU) during… compared with no rubber dam; GRADE not reported.

1 finding from 1 review

Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
MD 0.96 [-0.08, 2.00]
1 study · 47 participants
GRADE not reported

Horizontal mattress / fibrin sealant suturing vs Conventional (simple interrupted) suturing

Swelling (mean) · Adults with mandibular third molars requiring removal

The review found no eligible studies for this question.

1 finding from 1 review

Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes
7 days
no estimate extracted
Studies not reported
No studies found

Powered toothbrushing (as part of comprehensive oral care) vs Manual toothbrushing

Duration of ICU stay · Critically ill patients receiving mechanical ventilation in ICU

Powered toothbrushing (as part of comprehensive oral care) showed no clear difference in duration of ICU stay compared with manual toothbrushing (standard oral care); GRADE not reported.

1 finding from 1 review

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
MD -2.00 [-5.93, 1.93]
1 study · 78 participants
GRADE not reported

Counter-stimulation or distraction vs Conventional treatment

Patient satisfaction: measured by questionnaires · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes
Immediately before or during LA
Patient satisfaction: included studies did not report on this outcome
Studies not reported
No studies found

Clobetasol propionate ointment vs Clobetasol propionate 0.025% ointment

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate 0.05% ointment showed no clear difference in clinical score compared with clobetasol propionate 0.025% ointment (low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
MD 0.47 [-0.26, 1.20]
1 study · 30 participants
Low

Topical triamcinolone acetonide vs Topical ciclosporin

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
end of treatment
MD -0.23 [-1.02, 0.56]
1 study · 139 participants
GRADE not reported

Intervention not reported

Absence of recurrent caries success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Dentist experience: Experienced
Proportion 0.908 [0.861, 0.941]
28 studies
GRADE not reported