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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · All outcomes

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Pre-cooling of the injection site vs Conventional treatment

Completion of dental treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs6639060 and dental caries susceptibility (TT vs CC + CT model: OR 1.00, 95% CI 0.42-2.39) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review

Clinical examination with risk-based recall vs Clinical examination with 24-month recall

Oral health-related quality of life · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in oral-health-related quality of life (OHIP-14) compared with clinical examination with 24-month recall (high certainty).

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Incidence of symptomatic or test-positive COVID-19 infection in HCWs · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Powered toothbrushing (as part of comprehensive oral care) vs Manual toothbrushing

Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU

Powered toothbrushing (as part of comprehensive oral care) showed no clear difference in incidence of VAP compared with manual toothbrushing (standard oral care); GRADE not reported.

1 finding from 1 review

Audiovisual distraction vs Conventional treatment

Anxiety · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Audiovisual distraction led to lower pre- and post-operative anxiety measures (Modified Child Dental… compared with conventional treatment; GRADE not reported.

1 finding from 1 review

Higher dental caries experience vs Caries-free controls

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Higher dental caries experience was associated with substantially higher odds of poor OHRQoL (OR 1.66, 95% CI 1.43-1.88; 6 studies; high heterogeneity I2=83.5%; ungraded).

1 finding from 1 review

Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet

Caries experience (mean DMFT) · General population (children and adults) assessed for dental hard-tissue health

Among adults, the lower DMFT score in vegetarians was smaller and not statistically significant (mean difference -0.09, 95% CI -0.32 to 0.13; ungraded).

1 finding from 1 review

Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Caries incidence of occlusal surfaces of first permanent molars · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

After excluding Bravo 1996, occlusal caries incidence slightly favored fluoride varnish but was not significant, with heterogeneity falling to 0% (RR 0.98, 95% CI 0.82 to 1.16; 3 RCTs; ungraded).

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Cost (healthcare-system perspective): total cost per patient (GBP) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in cost (healthcare-system perspective): total cost per patient (GBP) compared with clinical examination with 6-month recall; GRADE not reported.

1 finding from 1 review