Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Patient education and standard care vs usual care

Flare‐ups or relapse (4‐12 months) (dichotomous outcome) · people with inflammatory bowel disease

It is very uncertain whether patient education and standard care changes flare‐ups or relapse (4‐12 months) (dichotomous outcome) compared with standard care (very low certainty).

1 finding from 1 review

Fecal microbiota transplantation vs control

Resolution of rCDI · adults with recurrent Clostridioides difficile infection (rCDI)

Summary of findings table ‐ Fecal microbiota transplantation (FMT) probably leads to higher resolution of rCDI compared with control (moderate certainty).

1 finding from 1 review

Fecal microbiota transplantation vs control

Serious adverse events · adults with recurrent Clostridioides difficile infection (rCDI)

Summary of findings table ‐ Fecal microbiota transplantation (FMT) showed no clear difference in serious adverse events compared with control (moderate certainty).

1 finding from 1 review

Fecal microbiota transplantation vs control

All‐cause mortality · adults with recurrent Clostridioides difficile infection (rCDI)

Summary of findings table ‐ Fecal microbiota transplantation (FMT) showed no clear difference in all‐cause mortality compared with control (low certainty).

1 finding from 1 review