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Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

996 questions · 1,049 findings · 79 reviews · Dementia and Cognitive Improvement

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No studies found 240 · 22.9%GRADE not reported 31 · 3%Very low 216 · 20.6%Low 253 · 24.1%Moderate 238 · 22.7%High 71 · 6.8%

Trazodone vs placebo

Number of participants reporting an adverse event · sleep disturbances in dementia

Trazodone showed no clear difference in reporting ≥ 1 adverse event compared with placebo (low certainty).

1 finding from 1 review

Orexin antagonists vs placebo

Number of participants reporting an adverse event · sleep disturbances in dementia

Orexin antagonists showed no clear difference in reporting ≥ 1 adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Melatonin vs placebo

Number of participants reporting an adverse event · sleep disturbances in dementia

Melatonin showed no clear difference in reporting ≥ 1 adverse event compared with placebo (low certainty).

1 finding from 1 review