evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy

Participant‐reported global assessment‐ total · Patients with osteoarthritis of the knee or hip

Summary of findings table ‐ Adjunctive therapies in addition to… probably leads to higher participant‐reported global assessment‐ total compared with land‐based exercise therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy

Adverse events · Patients with osteoarthritis of the knee or hip

Summary of findings table ‐ Adjunctive therapies in addition to… showed no clear difference in adverse events compared with land‐based exercise therapy (low certainty).

1 finding from 1 review

Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies

Adverse events · Patients with osteoarthritis of the knee or hip

Summary of findings table ‐ Adjunctive therapies in addition to… showed no clear difference in adverse events compared with placebo adjunctive therapies (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Mean change in pain from baseline (0‐ to 10‐point scale, 0 is no pain) at 8–16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in mean change in pain from baseline (0‐ to 10‐point scale, 0 is no… compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

At least 50% reduction in pain · predominantly knee osteoarthritis

Antidepressant leads to higher responder rate: ≥ 50% reduction in 24‐hour mean pain compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Physical function · predominantly knee osteoarthritis

Antidepressant showed no clear difference in mean change in physical function from baseline (0–100 WOMAC Total… compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0 indicates perfect health) between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo

Proportion of participants who withdrew due to adverse events between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).

1 finding from 1 review