Findings

What do systematic reviews say?

4,811 questions · 70,850 findings · 5,139 reviews

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No studies found 15,174 · 21.4%GRADE not reported 6,479 · 9.1%Very low 17,330 · 24.5%Low 17,814 · 25.1%Moderate 11,056 · 15.6%High 2,997 · 4.2%

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Full-time wear of removable retainer (any type) vs Part-time wear of removable retainer (any type)

Adverse effects on oral health · People who had received fixed appliance orthodontic treatment

The review found no eligible studies for this question.

1 finding from 1 review

Retention procedures for stabilising tooth position after treatment with orthodontic braces 2023 · Cochrane All outcomes
12 months · lower arch
Not measured
0 studies
No studies found

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Harms (orthodontically-induced inflammatory root resorption) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Light vibrational forces (LVF) showed no clear difference in harms and side effects: orthodontically-induced inflammatory root… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
MD 0.09 [-0.35, 0.53]
1 study · 50 participants
Low

Supraomohyoid neck dissection vs Modified radical neck dissection

Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Locoregional recurrence: reported but not usable (variable follow-up) (Guo 2014).
1 study
GRADE not reported

Fibre-reinforced composite fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Adverse effects on oral health: bleeding on probing (lower arch) · People who had received fixed appliance orthodontic treatment

The review found no eligible studies for this question.

1 finding from 1 review

Retention procedures for stabilising tooth position after treatment with orthodontic braces 2023 · Cochrane All outcomes
12 months · lower arch
No RCTs at 12-month follow-up; 1 RCT at 6 months found no difference (very low-certainty)
0 studies
No studies found

Hawley removable retainer vs Clear plastic removable retainer

Survival of retainers (failure/how many failed) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether hawley removable retainer changes survival of retainers (failure, upper and lower arches) compared with clear plastic removable retainer (very low certainty).

1 finding from 1 review

Retention procedures for stabilising tooth position after treatment with orthodontic braces 2023 · Cochrane All outcomes
12 months · upper and lower arches
RR 0.60 [0.43, 0.83]
1 study · 111 participants
Very low

Hawley removable retainer vs Clear plastic removable retainer

Patient satisfaction: comfort (VAS, upper and lower arches) · People who had received fixed appliance orthodontic treatment

The review found no eligible studies for this question.

1 finding from 1 review

Retention procedures for stabilising tooth position after treatment with orthodontic braces 2023 · Cochrane All outcomes
12 months · upper and lower arches
No RCTs at 12 months; 1 RCT at 6 months: Hawley less comfortable (VAS MD -1.86, 95% CI -2.19 to -1.53; very low-certainty)
0 studies
No studies found

Surgery vs Radiotherapy alone

Total mortality · Adults with oropharyngeal cancer

Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.83 [0.09, 7.46]
1 study · 68 participants
Low

Low‐level laser therapy vs Conventional orthodontic appliance treatment

Patient-reported need for analgesics · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
Patient-reported need for analgesics | Not reported
Studies not reported
No studies found

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower recurrence compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
RR 0.58 [0.48, 0.70]
3 studies · 633 participants
Moderate

Low‐level laser therapy vs Conventional orthodontic appliance treatment

Total number of orthodontic appliance adjustment appointments during treatment · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
No study reported on the influence of LLLT on the total number of orthodontic appliance adjustment visits to complete a course of treatment.
Studies not reported
No studies found

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Locoregional recurrence · Adults with oral cavity cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Locoregional recurrence: not reported.
0 studies
No studies found

Surgery vs Radiotherapy alone

Locoregional recurrence · Adults with oropharyngeal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Locoregional recurrence: not reported.
0 studies
No studies found

Surgery plus radiotherapy vs Radiotherapy alone

Recurrence · Adults with oral cavity or oropharyngeal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Recurrence: not reported.
0 studies
No studies found

Upper fixed (bonded) retainer vs No retention

Stability: Little's Irregularity Index (upper arch) · People who had received fixed appliance orthodontic treatment

Upper fixed (bonded) retainer led to lower stability: Little's Irregularity Index (upper arch) compared with no retention; GRADE not reported.

1 finding from 1 review

Retention procedures for stabilising tooth position after treatment with orthodontic braces 2023 · Cochrane All outcomes
2 years · upper arch
MD -0.90 [-1.33, -0.47]
1 study · 63 participants
GRADE not reported

Low‐level laser therapy vs Conventional orthodontic appliance treatment

Overall treatment time wearing orthodontic appliances · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
No study reported on the influence of LLLT on the total overall orthodontic treatment duration.
Studies not reported
No studies found

Surgery plus radiotherapy vs Chemotherapy (chemoradiotherapy)

Total mortality · Adults with oral cavity or oropharyngeal cancer

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
oral cavity
Total mortality: study reported survival significantly better with surgery and RT vs chemoradiotherapy, but no useable data; 32 participants (1 RCT, Iyer 2015 oral cavity subgroup).
1 study · 32 participants
Very low

Light-emitting diode (LED) photobiomodulation vs Conventional orthodontic appliance treatment

Orthodontic tooth movement (OTM) during alignment stage · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
Orthodontic tooth movement (OTM) during alignment stage | Not reported
Studies not reported
No studies found

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Harms: serious adverse effects · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
No serious adverse effects were reported across five studies that assessed harms (Katchooi 2018; Lombardo 2018; Pavlin 2015; Reiss 2020; Taha 2020).
5 studies
GRADE not reported

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Rate of orthodontic tooth movement (OTM) during space closure stage (en masse, mm/month) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Light vibrational forces (LVF) showed no clear difference in rate of orthodontic tooth movement (OTM) during space closure stage… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
Space closure stage
MD 0.10 [-0.08, 0.29]
2 studies · 81 participants
Low

Superselective neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
36 months
Disease-free survival: Pandey 2018 reported 83% (superselective) vs 91% (selective) at median 36 months, not significant (P=0.69); unable to analyse (variable follow-up); 32 participants (1 RCT).
1 study · 32 participants
Very low