Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,444 questions · 1,518 findings · 135 reviews · Infectious Diseases

No studies found 135 · 8.9%GRADE not reported 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%

Intervention not reported

Improvement of clinical status: all initial symptoms resolved (asymptomatic) at day 14 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in improvement of clinical status: all initial symptoms resolved… (low certainty).

1 finding from 1 review

Intervention not reported

Improvement of clinical status: time to symptom resolution · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

QoL (physical component) at up to 28 days, measured on the PROMIS Global‐10 scale and normalized to values from 16.2, low QoL, to 67.2, maximum QoL · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in qoL (physical component) at up to 28 days, measured on the PROMIS… (high certainty).

1 finding from 1 review

Intervention not reported

QoL (mental component) at up to 28 days, measured on the PROMIS Global‐10 scale and normalized to values from 21.2, low QoL, to 67.6, maximum QoL · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in qoL (mental component) at up to 28 days, measured on the PROMIS… (high certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in serious adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Any adverse events during the trial period · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in any adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance at day 7 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in viral clearance at day 7 (low certainty).

1 finding from 1 review

Intervention not reported

Worsening of clinical status: participants with new need for invasive mechanical ventilation or death at day 28 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes worsening of clinical status: participants with new need for… (very low certainty).

1 finding from 1 review

Intervention not reported

Improvement of clinical status: participants discharged alive at day 28 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The intervention showed no clear difference in improvement of clinical status: participants discharged alive at day… (low certainty).

1 finding from 1 review

Intervention not reported

QoL at longest · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes serious adverse events during the trial period (very low certainty).

1 finding from 1 review

Intervention not reported

Any adverse events during the trial period · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The intervention showed no clear difference in any adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance at day 7 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The intervention showed no clear difference in viral clearance at day 7 (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 28 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in all‐cause mortality at day 28 (moderate certainty).

1 finding from 1 review

Intervention not reported

Worsening of clinical status: admission to hospital or death within 28 days · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in worsening of clinical status: admission to hospital or death within… (low certainty).

1 finding from 1 review

Albendazole vs placebo or no anthelmintics

Seizure recurrence ‐ participants with a single cyst · people with neurocysticercosis

Albendazole probably leads to lower seizure recurrence ‐ participants with a single cyst compared with placebo or no anthelmintics (moderate certainty).

1 finding from 1 review

Albendazole vs placebo or no anthelmintics

Seizure recurrence ‐ participants with multiple (> 1) cysts · people with neurocysticercosis

It is very uncertain whether albendazole changes seizure recurrence ‐ participants with multiple (> 1) cysts compared with placebo or no anthelmintics (very low certainty).

1 finding from 1 review