What do systematic reviews say?

DHEA or testosterone vs placebo/no treatment

DHEA or testosterone probably leads to higher live birth/ongoing pregnancy rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 1.81 [1.25, 2.62]
  8 studies · 878 participants
  Moderate
• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 2.6 [1.3, 5.2]
  4 studies · 345 participants
  Moderate

Testosterone vs other active intervention

It is very uncertain whether testosterone changes live birth ‐ Testosterone vs estradiol + OCP compared with other active interventions (very low certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 1.67 [0.34, 8.1]
  1 study · 42 participants
  Very low
• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 2.06 [0.43, 9.87]
  1 study · 46 participants
  Very low

Testosterone vs other active intervention

It is very uncertain whether testosterone changes miscarriage ‐ Testosterone vs estradiol compared with other active interventions (very low certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 0.7 [0.11, 4.64]
  1 study · 46 participants
  Very low
• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 1.9 [0.16, 22.72]
  1 study · 42 participants
  Very low

Testosterone vs other active intervention

It is very uncertain whether testosterone changes clinical pregnancy rate ‐ Testosterone vs estradiol compared with other active interventions (very low certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 1.4 [0.39, 5.07]
  1 study · 46 participants
  Very low

Testosterone vs other active intervention

It is very uncertain whether testosterone changes clinical pregnancy rate ‐ Testosterone vs estradiol + OCP compared with other active interventions (very low certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 1.87 [0.45, 7.69]
  1 study · 42 participants
  Very low

DHEA or testosterone vs placebo/no treatment

DHEA or testosterone showed no clear difference in miscarriage rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 0.58 [0.29, 1.17]
  8 studies · 950 participants
  Moderate

DHEA or testosterone vs placebo/no treatment

DHEA or testosterone showed no clear difference in miscarriage rate ‐ Testosterone compared with placebo/no treatment (low certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 2.04 [0.58, 7.13]
  4 studies · 345 participants
  Low

DHEA or testosterone vs placebo/no treatment

DHEA or testosterone probably leads to higher clinical pregnancy rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 1.34 [1.01, 1.76]
  12 studies · 1246 participants
  Moderate

DHEA or testosterone vs placebo/no treatment

DHEA or testosterone probably leads to higher clinical pregnancy rate ‐ Testosterone compared with placebo/no treatment (moderate certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 2.52 [1.36, 4.68]
  4 studies · 345 participants
  Moderate

DHEA or testosterone vs placebo/no treatment

It is very uncertain whether DHEA or testosterone changes multiple pregnancy ‐ DHEA compared with placebo/no treatment (very low certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 3.23 [0.13, 81.01]
  5 studies · 267 participants
  Very low
• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 3.09 [0.48, 19.98]
  3 studies · 292 participants
  Very low

Radially expanding trocars vs cutting trocars

It is very uncertain whether radially expanding trocars changes visceral injury compared with cutting trocars (very low certainty).

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  OR 0.95 [0.06, 15.32]
  4 studies · 473 participants
  Very low

Conical blunt‐tipped trocar vs cutting trocars

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 42 participants
  Very low

Radially expanding trocars vs Blunt trocars

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Very low

Radially expanding trocars vs Blunt trocars

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Very low

Radially expanding trocars vs Blunt trocars

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Very low

Single‐bladed trocar vs pyramidal‐bladed trocar

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Very low

Single‐bladed trocar vs pyramidal‐bladed trocar

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Very low

Single‐bladed trocar vs pyramidal‐bladed trocar

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Very low

Radially expanding trocars vs cutting trocars

It is very uncertain whether radially expanding trocars changes vascular injury compared with cutting trocars (very low certainty).

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  OR 0.14 [0, 7.16]
  4 studies · 473 participants
  Very low

Radially expanding trocars vs cutting trocars

• Trocar types in laparoscopy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 463 participants
  Very low