Adverse events Beta‐estradiol patch 0.05 or 0.1 mg/day vs CEE 0.625 or 1.25 mg/day · women with hot flushes
1 finding from 1 review
Frequency of hot flushes Oral beta‐estradiol 1.0 and 2.0 mg/day vs CEE 0.625 or 1.25 mg/day · women with hot flushes
1 finding from 1 review
Adverse events Oral beta‐estradiol 1.0 or 2.0 mg/day vs CEE 0.625 or 1.25 mg/day · women with hot flushes
1 finding from 1 review
Intensity of hot flushes Beta‐estradiol patch 0.025‐0.05 mg/day · women with hot flushes
Transdermal beta‐estradiol patch showed no clear difference in intensity of hot flushes Beta‐estradiol patch 0.025‐0.05 mg/day compared with placebo (low certainty).
1 finding from 1 review
Adverse effects Beta‐estradiol patch dose 0.10 mg/day · women with hot flushes
Transdermal beta‐estradiol patch may leads to higher adverse effects Beta‐estradiol patch dose 0.10 mg/day compared with placebo (low certainty).
1 finding from 1 review
Hot flush frequency (number/day) · women with hot flushes
1 finding from 1 review
Adverse effects Beta‐estradiol gel dose 1.5 mg/day · women with hot flushes
1 finding from 1 review
Hot flush frequency (number/day) · women with hot flushes
Oral beta‐estradiol showed no clear difference in frequency of hot flushes Oral beta‐estradiol 0.5‐1.0 mg/day compared with placebo (low certainty).
1 finding from 1 review
Adverse effects Oral beta‐estradiol 0.5‐2.0 mg/day · women with hot flushes
1 finding from 1 review
Rate of vasomotor symptoms ‐ · women with vasomotor symptoms
1 finding from 1 review
Adverse effects Micellar nanoparticle beta‐estradiol 8.6 mg/day · women with vasomotor symptoms
Topical beta‐estradiol emulsion showed no clear difference in adverse effects Micellar nanoparticle beta‐estradiol 8.6 mg/day compared with placebo (low certainty).
1 finding from 1 review
Anxiety · Subfertile men and women
1 finding from 1 review
Depressive symptoms · Subfertile men and women
1 finding from 1 review
Live birth or ongoing pregnancy · Subfertile men and women
1 finding from 1 review
Relief of pain · women with primary dysmenorrhoea
NSAIDs may leads to higher pain relief dichotomous data compared with placebo (low certainty).
1 finding from 1 review
OR 4.37 [3.76, 5.09]
Studies not reported
Low
All adverse effects · women with primary dysmenorrhoea
NSAIDs may leads to higher all adverse effects compared with placebo (low certainty).
1 finding from 1 review
OR 1.29 [1.11, 1.51]
Studies not reported
Low
Relief of pain · women with primary dysmenorrhoea
NSAIDs may leads to higher pain relief dichotomous data compared with paracetamol (low certainty).
1 finding from 1 review
OR 1.89 [1.05, 3.43]
Studies not reported
Low
All adverse effects ‐ ibuprofen versus paracetamol · women with primary dysmenorrhoea
It is very uncertain whether NSAIDs changes all adverse effects ‐ ibuprofen versus paracetamol compared with paracetamol (very low certainty).
1 finding from 1 review
OR 0.85 [0.31, 2.34]
Studies not reported
Very low
Ease of dilatation: need for mechanical dilatation · Pre and post menopausal women
Misoprostol probably leads to lower ease of dilatation: need for mechanical dilatation compared with placebo or no treatment before operative hysteroscopy (moderate certainty).
1 finding from 1 review
Side effects · Pre and post menopausal women
1 finding from 1 review
no estimate extracted
Studies not reported
Low