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Evidence found and GRADE certainty

2,079 questions · 2,112 findings · 171 reviews · Eyes and Vision

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No studies found 587 · 27.8%GRADE not reported 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Intervention not reported

Contrast threshold loss ‐0.15 log units or more at 1 year · patients with choroidal neovascularisation secondary to age‐related macular degeneration

The intervention showed no clear difference in contrast threshold loss ‐0.15 log units or more at 1 year (moderate certainty).

1 finding from 1 review

Intervention not reported

Reading speed 40 word/minute or more after 1 year · patients with choroidal neovascularisation secondary to age‐related macular degeneration

The intervention showed no clear difference in reading speed 40 word/minute or more after 1 year (high certainty).

1 finding from 1 review

Intervention not reported

Loss of 6+ points of overall NEI‐VFQ score at 1 year · patients with choroidal neovascularisation secondary to age‐related macular degeneration

The intervention may leads to higher loss of 6+ points of overall NEI‐VFQ score at 1 year (low certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

BCVA: loss of 15 or more ETDRS letters · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to lower loss of 3 or more lines (15 or more letters) visual acuity ETDRS chart compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Six or more lines visual acuity lost · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to lower loss of 6 or more lines (30 or more letters) visual acuity ETDRS chart compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to higher gain of 3 or more lines (15 or more letters) compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Adverse effects: acute severe visual acuity decrease · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin showed no clear difference in adverse effects: acute severe visual acuity decrease compared with photodynamic therapy with 5% dextrose (moderate certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Adverse effects: infusion‐related back pain · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to higher adverse effects: infusion‐related back pain compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Intervention not reported

Trabeculectomy failure at 12 months · People undergoing trabeculectomy surgery with glaucoma

The intervention probably leads to lower trabeculectomy failure at 12 months (moderate certainty).

1 finding from 1 review

Intervention not reported

mean intraocular pressure mmHg at 12 months · People undergoing trabeculectomy surgery with glaucoma
1 finding from 1 review

Intervention not reported

complications wound leak by 12 months · People undergoing trabeculectomy surgery with glaucoma

The intervention showed no clear difference in complications wound leak by 12 months (low certainty).

1 finding from 1 review

Intervention not reported

complications hypotony occurring up to 12 months · People undergoing trabeculectomy surgery with glaucoma

The intervention showed no clear difference in complications hypotony occurring up to 12 months (low certainty).

1 finding from 1 review

Intervention not reported

complications shallow anterior chamber occurring within 12 months · People undergoing trabeculectomy surgery with glaucoma

The intervention showed no clear difference in complications shallow anterior chamber occurring within 12 months (low certainty).

1 finding from 1 review

Intervention not reported

cataract formation by 12 months · People undergoing trabeculectomy surgery with glaucoma

The intervention showed no clear difference in cataract formation by 12 months (moderate certainty).

1 finding from 1 review