Findings

What do systematic reviews say?

1,187 questions · 1,248 findings · 108 reviews · Stroke

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No studies found 275 · 22%GRADE not reported 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Shunting vs no shunting

Any stroke within 24 hours of surgery · patients with symptomatic or asymptomatic carotid disease

Shunting may leads to lower any stroke within 24 hours of surgery compared with no shunting (low certainty).

1 finding from 1 review

Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring in… 2022 · Cochrane Headline outcomes only
OR 0.15 [0.03, 0.78]
2 studies · 214 participants
Low

Shunting vs no shunting

Stroke · patients with symptomatic or asymptomatic carotid disease

Shunting showed no clear difference in any stroke within 30 days of surgery compared with no shunting (low certainty).

1 finding from 1 review

Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring in… 2022 · Cochrane Headline outcomes only
OR 0.77 [0.35, 1.69]
3 studies · 655 participants
Low

Intervention not reported

Poor outcome

The intervention showed no clear difference in poor outcome (high certainty).

1 finding from 1 review

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage 2022 · Cochrane Headline outcomes only
RR 1.03 [0.94, 1.13]
5 studies · 2359 participants
High

Intervention not reported

All cause mortality

The intervention showed no clear difference in all cause mortality (high certainty).

1 finding from 1 review

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage 2022 · Cochrane Headline outcomes only
RR 1.02 [0.9, 1.16]
11 studies · 2717 participants
High

Intervention not reported

Rebleeding

The intervention probably leads to lower rebleeding (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage 2022 · Cochrane Headline outcomes only
RR 0.65 [0.47, 0.91]
11 studies · 2717 participants
Moderate

Intervention not reported

Delayed cerebral ischemia

The intervention showed no clear difference in delayed cerebral ischemia (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage 2022 · Cochrane Headline outcomes only
RR 1.27 [1, 1.62]
7 studies · 2484 participants
Moderate

Intervention not reported

Hydrocephalus

The intervention showed no clear difference in hydrocephalus (high certainty).

1 finding from 1 review

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage 2022 · Cochrane Headline outcomes only
RR 1.09 [0.99, 1.2]
6 studies · 1992 participants
High

Pharmaceutical interventions vs placebo

Emotionalism (primary outcome) · emotionalism after stroke

It is very uncertain whether pharmaceutical interventions changes emotionalism (primary outcome) compared with placebo (very low certainty).

1 finding from 1 review

Pharmaceutical interventions for emotionalism after stroke 2022 · Cochrane Headline outcomes only
RR 0.26 [0.09, 0.77]
1 study · 19 participants
Very low

Pharmaceutical interventions vs placebo

Emotionalism: mean scores at end of treatment ‐ Pathological Laughter and Crying Scale · emotionalism after stroke

1 finding from 1 review

Pharmaceutical interventions for emotionalism after stroke 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Pharmaceutical interventions vs placebo

Depression: Mean scores at end of treatment · emotionalism after stroke

1 finding from 1 review

Pharmaceutical interventions for emotionalism after stroke 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low

Pharmaceutical interventions vs placebo

Cognitive function · emotionalism after stroke

1 finding from 1 review

Pharmaceutical interventions for emotionalism after stroke 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Pharmaceutical interventions vs placebo

Activities of daily living · emotionalism after stroke

1 finding from 1 review

Pharmaceutical interventions for emotionalism after stroke 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Pharmaceutical interventions vs placebo

Adverse events: 1. death: at end of treatment · emotionalism after stroke

Pharmaceutical interventions showed no clear difference in adverse events: 1. death: at end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Pharmaceutical interventions for emotionalism after stroke 2022 · Cochrane Headline outcomes only
RR 0.59 [0.08, 4.5]
6 studies · 172 participants
Moderate

Occupational therapy vs usual care

BADL (primary outcome) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Occupational therapy vs usual care

5a. Visual attention overall (postintervention) · adults with cognitive impairment after stroke

2 findings from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 620 participants
Low
Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 293 participants
Low

Occupational therapy vs usual care

5c. Sustained visual attention (postintervention) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 463 participants
Moderate

Occupational therapy vs usual care

Memory (specific cognitive function) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
6 participants
GRADE not reported

Occupational therapy vs usual care

Cognitive subdomain: working memory measured at the end of · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 420 participants
Low

Occupational therapy vs usual care

6b. Immediate verbal memory span (postintervention) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 357 participants
Very low

Occupational therapy vs usual care

6c. Immediate spatial memory span (postintervention) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 292 participants
Low