Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,337 questions · 1,354 findings · 566 reviews

No studies found 307 · 22.7%GRADE not reported 81 · 6%Very low 424 · 31.3%Low 310 · 22.9%Moderate 189 · 14%High 43 · 3.2%

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Serious adverse events at longest · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to higher serious adverse events (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events for neonate/infant · pregnant women and their babies

The intervention may leads to lower serious adverse events for neonate/infant (low certainty).

1 finding from 1 review

Thiazolidinediones vs no intervention

Serious adverse events (number of events) · people with non‐alcohol‐related fatty liver disease (NAFLD)

It is very uncertain whether thiazolidinediones changes serious adverse events (number of events) compared with no intervention (very low certainty).

1 finding from 1 review