Findings

What do systematic reviews say?

16 questions · 16 findings · 5 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 3 · 18.8%GRADE not reported 0 · 0%Very low 2 · 12.5%Low 6 · 37.5%Moderate 4 · 25%High 1 · 6.3%

Summary of findings 1: PLD with chemotherapy vs alternative combination chemotherapy

QoL · platinum‐sensitive recurrent EOC

1 finding from 1 review

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 608 participants
Low

Chemotherapy with TKI (peptide‐Fc fusion protein) followed by TKI maintenance vs chemotherapy alone

QoL · newly‐diagnosed EOC

The review found no eligible studies for this question.

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Chemotherapy with bevacizumab followed by bevacizumab maintenance vs chemotherapy alone

QoL · platinum‐sensitive recurrent EOC

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 486 participants
Low

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

QoL · platinum‐sensitive recurrent EOC

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Chemotherapy with bevacizumab followed by bevacizumab maintenance vs chemotherapy alone

QoL · newly‐diagnosed EOC

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 890 participants
High

Chemotherapy with TKI vs chemotherapy alone

QoL · recurrent platinum‐resistant EOC

Chemotherapy with TKI showed no clear difference in quality of life (QoL) compared with chemotherapy alone (low certainty).

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 164 participants
Low

Chemotherapy with TKI (peptide‐Fc fusion protein) vs chemotherapy alone

QoL · recurrent EOC

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 315 participants
Low

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

QoL · newly‐diagnosed EOC

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1340 participants
Moderate

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi monotherapy vs chemotherapy alone

QoL · platinum‐sensitive recurrent EOC

1 finding from 1 review

Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 229 participants
Low

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi with chemotherapy vs chemotherapy alone

QoL · newly‐diagnosed EOC

1 finding from 1 review

Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 744 participants
Moderate

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy vs placebo (maintenance therapy)

QoL · newly‐diagnosed EOC

1 finding from 1 review

Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 362 participants
Moderate

Bethanechol vs placebo

QoL

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Suprapubic catheterisation vs intermittent self‐catheterisation

QoL

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis

1 finding from 1 review

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis

1 finding from 1 review

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi monotherapy vs placebo (maintenance therapy)

QoL · platinum‐sensitive recurrent EOC

1 finding from 1 review

Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 339 participants
Moderate