Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).
It is very uncertain whether tramadol alone changes number of participants who withdrew due to adverse events compared with acetaminophen (very low certainty).
Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with NSAIDs (low certainty).
Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with other opioids (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Tramadol alone probably leads to higher number of participants who withdrew due to adverse events compared with placebo (moderate certainty).
Bisphosphonates showed no clear difference in number of participants who withdrew due to adverse events compared with placebo (low certainty).
It is very uncertain whether zoledronate changes number of participants who withdrew due to adverse events… compared with pamidronate or risedronate (very low certainty).