Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Stroke

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 25%High 3 · 75%

GLP‐1RA vs placebo

Fatal or nonfatal myocardial infarction · CVD (ASCVD, HF, or both)

GLP‐1RA showed no clear difference in myocardial infarction (fatal or non‐fatal) compared with placebo (moderate certainty).

1 finding from 1 review

Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2… 2021 · Cochrane Headline outcomes only
OR 0.89 [0.78, 1.01]
5 studies · 42910 participants
Moderate

DPP4i vs placebo

Fatal or nonfatal myocardial infarction · CVD (ASCVD, HF, or both)

DPP4i showed no clear difference in myocardial infarction (fatal or non‐fatal) compared with placebo (high certainty).

1 finding from 1 review

Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2… 2021 · Cochrane Headline outcomes only
OR 0.97 [0.88, 1.08]
4 studies · 42334 participants
High

SGLT2i vs placebo

Fatal or nonfatal myocardial infarction · CVD (ASCVD, HF, or both)

SGLT2i showed no clear difference in myocardial infarction (fatal or non‐fatal) compared with placebo (high certainty).

1 finding from 1 review

Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2… 2021 · Cochrane Headline outcomes only
OR 0.97 [0.84, 1.12]
2 studies · 15266 participants
High

Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment

Stroke, myocardial infarction, or vascular death · stroke and/or TIA

Blood pressure‐lowering drugs (BPLDs) showed no clear difference in major vascular event (composite of non‐fatal stroke, non‐fatal… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Blood pressure‐lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients… 2018 · Cochrane Headline outcomes only
RR 0.9 [0.78, 1.04]
4 studies · 28630 participants
High