Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

90 questions · 96 findings · 27 reviews · Vascular

No studies found 10 · 10.4%GRADE not reported 11 · 11.5%Very low 18 · 18.8%Low 28 · 29.2%Moderate 23 · 24%High 6 · 6.3%

Oral factor Xa inhibitors vs conventional anticoagulation

Major bleedinge · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in major bleedinge compared with conventional anticoagulation (low certainty).

1 finding from 1 review

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Major bleedinge · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in major bleedinge compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Outpatient vs inpatient treatment

Major bleeding · people with low‐risk acute pulmonary embolism

Outpatient showed no clear difference in major bleeding compared with inpatient treatment (low certainty).

2 findings from 1 review

Intervention not reported

Major bleeding ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes major bleeding ( (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs active control

Major bleeding · ambulatory cancer patients receiving chemotherapy

The review found no eligible studies for this question.

3 findings from 1 review