Anticoagulant vs different dose of the same anticoagulant
- Prophylactic anticoagulants for non‐hospitalised people with COVID‐19 2023 · Cochrane Headline outcomes onlyno estimate extracted1 study · 278 participantsModerate
Anticoagulant showed no clear difference in major bleeding compared with placebo or no treatment (low certainty).
Outpatient showed no clear difference in major bleeding compared with inpatient treatment (low certainty).
Chronic DVT ‐ antiplatelet agents plus BMP showed no clear difference in major bleeding compared with BMP plus placebo (moderate certainty).
It is very uncertain whether ultrasound‐accelerated thrombolysis changes major bleeding compared with thrombolysis alone (very low certainty).
It is very uncertain whether heparin started before changes major bleeding compared with after the surgical procedure (very low certainty).
Higher‐dose heparin showed no clear difference in major bleeding compared with standard‐dose heparin (low certainty).
It is very uncertain whether heparin changes major bleeding compared with pentasaccharide (very low certainty).
The review found no eligible studies for this question.
DOAC showed no clear difference in major bleeding compared with placebo (moderate certainty).
Ultra‐low‐molecular‐weight heparin showed no clear difference in major bleeding compared with placebo (moderate certainty).
The review found no eligible studies for this question.
Vitamin K antagonists showed no clear difference in major bleeding compared with placebo or no thromboprophylaxis (low certainty).
Vitamin K antagonists showed no clear difference in major bleeding compared with active control (low certainty).
It is very uncertain whether antithrombin changes major bleeding compared with no thromboprophylaxis (very low certainty).
Low‐molecular‐weight heparin probably leads to higher major bleeding compared with no thromboprophylaxis (moderate certainty).