Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 1 · 25%High 1 · 25%

Phenobarbital vs control

All deaths during the study · preterm infants with or at risk of IVH

Phenobarbital showed no clear difference in all deaths during the study compared with control (low certainty).

1 finding from 1 review

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.98 [0.72, 1.33]
10 studies · 792 participants
Low

Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation

All‐cause mortality · adults and children with sickle cell disease and an increased risk of stroke

Summary of findings ‐ Hydroxyurea and phlebotomy showed no clear difference in death during the study (all deaths) compared with transfusion and chelation (low certainty).

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
RR 0.99 [0.06, 15.42]
2 studies · 254 participants
Low

Hydroxyurea vs placebo

All‐cause mortality · people with sickle cell disease

Summary of findings ‐ Hydroxyurea showed no clear difference in death during the study (all deaths) compared with placebo (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
RR 0.65 [0.19, 2.27]
5 studies · 784 participants
Moderate

Vaccination vs placebo

Death during whole · people at risk for postherpetic neuralgia

Vaccination showed no clear difference in deaths among all subjects during the whole study clinical compared with placebo (high certainty).

1 finding from 1 review

Vaccination for preventing postherpetic neuralgia 2011 · Cochrane Headline outcomes only
RR 1 [0.91, 1.1]
1 study · 38546 participants
High