Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Cleft lip and/or palate (CL/P) vs Healthy controls without cleft

Clinical attachment level (CAL) · Individuals assessed for periodontal health (mainly children and adolescents, age >2 years)

Clinical attachment level loss is greater in persons with orofacial cleft than in healthy controls (p<0.00001), but no pooled effect size was reported (ungraded).

1 finding from 1 review

Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and… 2025 All outcomes
Clinical dental examination; various countries (e.g., Brazil, India, China, Thailand, USA)
The loss of clinical attachment level (CAL) is greater in patients with cleft lip and palate than in healthy controls (p < 0.00001)
Studies not reported
GRADE not reported

Lacunar stroke (cases) vs Without lacunar stroke (controls)

Clinical attachment level (CAL) · adults

Patients with lacunar stroke had greater clinical attachment loss than those without (MD 1.34); ungraded, with substantial heterogeneity (I2 = 95%).

1 finding from 1 review

The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study. 2025 All outcomes
Clinical (Japan and Republic of Chile)
MD 1.34 [0.63, 2.05]
4 studies
GRADE not reported