Findings

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5 questions · 5 findings · 2 reviews · Heart

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No studies found 0 · 0%GRADE not reported 1 · 20%Very low 0 · 0%Low 1 · 20%Moderate 1 · 20%High 2 · 40%

Alirocumab vs ezetimibe and statins

Stroke · people at high risk of CVD (history of CVD or high LDL‐C despite treatment)

Alirocumab showed no clear difference in any stroke compared with ezetimibe and statins (low certainty).

1 finding from 1 review

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
OR 0.85 [0.13, 5.61]
5 studies · 1734 participants
Low

Evolocumab vs ezetimibe and statins

Stroke · people at high risk of CVD (history of CVD or high LDL‐C despite treatment)

1 finding from 1 review

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 3899 participants
GRADE not reported

Alirocumab vs placebo

Stroke · people at high risk of CVD (history of CVD or high LDL‐C despite treatment)

Alirocumab leads to lower any stroke compared with placebo (high certainty).

1 finding from 1 review

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
OR 0.73 [0.58, 0.91]
8 studies · 22835 participants
High

Evolocumab vs placebo

Stroke · people at high risk of CVD (history of CVD or high LDL‐C despite treatment)

Evolocumab leads to lower any stroke compared with placebo (high certainty).

1 finding from 1 review

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
OR 0.79 [0.65, 0.94]
2 studies · 28531 participants
High

Remote ischaemic preconditioning (RIPC) vs no RIPC

Composite endpoint (including all‐cause mortality, non‐fatal myocardial infarction and/or any new stroke assessed at 30 days after surgery) · people undergoing CABG (with or without valve surgery)

RIPC showed no clear difference in composite endpoint (including all‐cause mortality, non‐fatal… compared with no RIPC (moderate certainty).

1 finding from 1 review

Remote ischaemic preconditioning for coronary artery bypass grafting (with or without valve surgery) 2017 · Cochrane Headline outcomes only
RR 0.99 [0.78, 1.25]
2 studies · 2463 participants
Moderate