Findings

What do systematic reviews say?

8 questions · 12 findings · 2 reviews · Infectious Diseases

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 41.7%Low 3 · 25%Moderate 4 · 33.3%High 0 · 0%

All‐cause death · children

Rotarix showed no clear difference in all‐cause death compared with placebo (moderate certainty).

3 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 1.27 [0.89, 1.81]
9 studies · 77043 participants
Moderate
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.88 [0.63, 1.21]
11 studies · 8374 participants
Moderate
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.71 [0.17, 2.88]
10 studies · 20361 participants
Low

All‐cause death · children

RotaTeq showed no clear difference in all‐cause death compared with placebo (low certainty).

3 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 1.24 [0.69, 2.22]
6 studies · 72654 participants
Low
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.33 [0.01, 8.18]
2 studies · 4088 participants
Very low
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.91 [0.68, 1.23]
3 studies · 7706 participants
Moderate

All‐cause death · children

Rotasiil showed no clear difference in all‐cause death compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 1.14 [0.82, 1.59]
2 studies · 11586 participants
Moderate

All‐cause death · children

It is very uncertain whether rotavac changes all‐cause death compared with placebo (very low certainty).

1 finding from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.88 [0.5, 1.56]
2 studies · 8155 participants
Very low

Mortality All‐cause death · Pregnant women (parity 0‐1)

It is very uncertain whether the intervention changes mortality All‐cause death (very low certainty).

1 finding from 1 review

Mortality All‐cause death · Pregnant women (parity 2+)

It is very uncertain whether the intervention changes mortality All‐cause death (very low certainty).

1 finding from 1 review

Mortality All‐cause death · Pregnant women (all parities)

The intervention showed no clear difference in mortality All‐cause death (low certainty).

1 finding from 1 review

Mortality All‐cause death · Pregnant women (parity 0‐1)

It is very uncertain whether the intervention changes mortality All‐cause death (very low certainty).

1 finding from 1 review