What do systematic reviews say?

Clonidine and opioid vs opioid

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with opioid alone (very low certainty).

• Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  RR 3 [0.13, 71.51]
  1 study · 80 participants
  Very low

Clonidine and opioid vs phenobarbital and opioid

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with phenobarbital and opioid (very low certainty).

• Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  RR 1.55 [0.44, 5.4]
  2 studies · 93 participants
  Very low

Morphine vs methadone

Morphine showed no clear difference in adverse events (treatment related) To discharge compared with methadone (low certainty).

• Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  RR 0.33 [0.01, 8.02]
  1 study · 116 participants
  Low

Morphine vs buprenorphine

It is very uncertain whether morphine changes adverse events (treatment‐related) To discharge compared with buprenorphine (very low certainty).

• Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  RR 0.33 [0.01, 7.5]
  3 studies · 113 participants
  Very low

Morphine vs dilute tincture of opium

The review found no eligible studies for this question.

• Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioids vs clonidine

The review found no eligible studies for this question.

• Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioids vs diazepam

The review found no eligible studies for this question.

• Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioids vs phenobarbital

• Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 96 participants
  Low

Opioids vs Placebo, no intervention or usual care (with or without placebo)

The review found no eligible studies for this question.

• Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found