Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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VALPROATE + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

VALPROATE + ANTIPSYCHOTICS showed no clear difference in leaving the study early: Overall tolerability Leaving the study… compared with ANTIPSYCHOTICS + PLACEBO or ANTIPSYCHOTICS alone (low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Movement disorder requiring the use of anti‐EPS medication ‐ medium term · patients with schizophrenia

RISPERIDONE DEPOT probably leads to higher adverse events: Movement disorder requiring the use of anti‐EPS… compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Systemic adverse events at · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in participants with adverse events ‐ systemic adverse eventsClinical… compared with placebo (moderate certainty).

1 finding from 1 review

Brivaracetam vs placebo

Withdrawals due to adverse events · people with drug‐resistant focal epilepsy

Brivaracetam may leads to higher proportion of participants who experienced adverse events leading to… compared with placebo (low certainty).

1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Primary: adverse events ‐ any adverse event treatment‐related (application site pruritus) · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: adverse events ‐ any adverse event treatment‐related… compared with vehicle foam (moderate certainty).

1 finding from 1 review

Nicotine EC vs behavioural support only/no support

Serious adverse events – measured by self‐report and medical records · people who smoke

It is very uncertain whether nicotine EC changes serious adverse events at 4 weeks to 8 months Assessed via… compared with behavioural support only/no support (very low certainty).

1 finding from 1 review

Baclofen vs acamprosate

Adverse events as N of participants with at least one adverse event subjective and objective · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes adverse events: number of participants with at least one adverse… compared with acamprosate (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U

Major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events ‐ Any major adverse events (eyelid ptosis,… compared with onabotulinumtoxinA 20U (moderate certainty).

1 finding from 1 review

Regimens containing quinolone vs regimens containing cephalosporin

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing quinolone changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporins (very low certainty).

1 finding from 1 review

Regimens containing nitroimidazole vs no nitroimidazole

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing nitroimidazole showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with no nitroimidazole (low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing quinolone

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing quinolone (very low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing cephalosporin

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporin (very low certainty).

1 finding from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review

Salt bath + UVB vs UVB alone

Number of adverse events requiring discontinuation of treatment ‐ not reported · people with chronic plaque psoriasis

Salt bath + UVB showed no clear difference in treatment‐related adverse events requiring withdrawal (number of… compared with UVB alone (low certainty).

1 finding from 1 review

Electromechanical and robotic assisted training vs other interventions

acceptability and safety of treadmill training ‐ No intervention control group (co‐interventions were not similar in both groups) Number of adverse events and drop‐outs · people with stroke
1 finding from 1 review

Alemtuzumab 12 mg vs interferon beta‐1a

Adverse events, including serious adverse events Assessed by: number of participants with ≥ 1 event · adults with relapsing–remitting multiple sclerosis

Alemtuzumab 12 mg showed no clear difference in adverse events, including serious events Assessed by: number of… compared with interferon beta‐1a (low certainty).

1 finding from 1 review

Fecal microbiota transplantation vs control

Any adverse events with use of FMT for induction of remission in UC (RR > 1 favors control) · people with active UC

Fecal microbiota transplantation showed no clear difference in any adverse events with use of FMT for induction of remission in UC… compared with control (low certainty).

1 finding from 1 review

Psychosocial interventions vs inactive control

Adverse events (a count of reported harms or adverse events/experiences over life of study/ · survivors of sexual violence and abuse

It is very uncertain whether summary of findings table ‐ Psychosocial interventions changes adverse events (a count of reported harms or adverse… compared with inactive control (very low certainty).

1 finding from 1 review